{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:03:48Z","timestamp":1773493428249,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Rumex dentatus<\/jats:italic>\n                    <jats:italic>L<\/jats:italic>\n                    . is an annual herb commonly known as \u201cAbuj\u201d (Kashmir) and as toothed dock and Aegean dock (worldwide).\n                    <jats:italic>R. dentatus<\/jats:italic>\n                    <jats:italic>L<\/jats:italic>\n                    . has a strong accord of antitumor, antidermatitis, anti\u2010inflammatory, diuretic, astringent, and bactericidal properties. To investigate the in vitro neuroprotective effects against corticosterone\u2010induced impairment using extracts and isolated compounds from\n                    <jats:italic>R. dentatus<\/jats:italic>\n                    <jats:italic>L<\/jats:italic>\n                    ., via neuronal impairment activating the BDNF\u2013TrkB pathway. Isolation and analysis were performed by column chromatography. Spectroscopy (\n                    <jats:sup>1<\/jats:sup>\n                    H NMR,\n                    <jats:sup>13<\/jats:sup>\n                    C NMR, and HRMS) were applied for structural elucidation of isolated compounds. All the isolates were tested for the possible in vitro neuroprotection against corticosterone\u2010prompted impairment, activating the BDNF\u2013TrkB pathway, performed using electronic databases, including PubMed, Google Scholar, and Science Net, to ensure the manuscript quality. The comparative study was made with different extracts of\n                    <jats:italic>R. dentatus<\/jats:italic>\n                    <jats:italic>L<\/jats:italic>\n                    ., and it was found that extracts showed remarkable antidepressant activity, which was overpowered by isolated compounds, particularly compound R3, found to be most effective. Among the panel of screened compounds, only R3 exhibited robust neurotropic activity, which increased neuronal cell survival in differentiated human neuroblastoma cells from high\u2010dose corticosterone (400\u00a0\u00b5M) induced cell death. Small natural molecule R3 prevents corticosterone\u2010induced neuronal impairment, activating the BDNF\u2013TrkB pathway. In conclusion,\n                    <jats:italic>R. dentatus<\/jats:italic>\n                    L. was evaluated for the isolation of bioactive secondary metabolite composition and neuroprotection. The isolation from the root extract of chloroform and methanol fractions led to five isolates. Three natural compounds, R1, OA, and R3, were found to have promising neuroprotective potential, confirmed through in vitro testing of the isolated constituents and effects against corticosterone\u2010induced impairment. The activation of the AKT\/ERK pathway by R3 showed significant cell survival and increased neural viability in corticosterone\u2010induced impairment in SHSY5Y cells in a concentration\u2010 and time\u2010dependent manner. The research finding is the first of its kind where\n                    <jats:italic>R. dentatus<\/jats:italic>\n                    has been used for isolation and bio\u2010evaluation with productive results.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500147","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T07:40:33Z","timestamp":1753774833000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Vitro Neuroprotection Against Corticosterone Prompted Impairment Activating BDNF\u2013TrkB Pathway Through Bioactive Secondary Metabolites Isolated From\n                    <i>Rumex dentatus<\/i>"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3888-1777","authenticated-orcid":false,"given":"Tahirah","family":"Khaliq","sequence":"first","affiliation":[{"name":"Plant Molecular Biology and Biotechnology Division CSIR\u2010Indian Institute of Integrative Medicine  Srinagar India"},{"name":"Academy of Scientific &amp; Innovative Research (AcSIR)  Ghaziabad Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loveleena","family":"Kaur","sequence":"additional","affiliation":[{"name":"Academy of Scientific &amp; Innovative Research (AcSIR)  Ghaziabad Uttar Pradesh India"},{"name":"Cancer Pharmacology Division CSIR\u2010Indian Institute of Integrative Medicine  Srinagar India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malik A.","family":"Waseem","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Products and Organic Synthesis, Department of Chemistry University of Kashmir  Srinagar India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phalisteen","family":"Sultan","sequence":"additional","affiliation":[{"name":"Plant Molecular Biology and Biotechnology Division CSIR\u2010Indian Institute of Integrative Medicine  Srinagar India"},{"name":"Academy of Scientific &amp; Innovative Research (AcSIR)  Ghaziabad Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fayaz A.","family":"Malik","sequence":"additional","affiliation":[{"name":"Academy of Scientific &amp; Innovative Research (AcSIR)  Ghaziabad Uttar Pradesh India"},{"name":"Cancer Pharmacology Division CSIR\u2010Indian Institute of Integrative Medicine  Srinagar India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qazi Parvaiz","family":"Hassan","sequence":"additional","affiliation":[{"name":"Plant Molecular Biology and Biotechnology Division CSIR\u2010Indian Institute of Integrative Medicine  Srinagar India"},{"name":"Academy of Scientific &amp; Innovative Research (AcSIR)  Ghaziabad Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13237-022-00405-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202300447"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ddc3010011"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573401319666230816141305"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ddc3010011"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano13030574"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7099"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27041204"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e14159"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e33342"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8649119"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871525718666200219140729"},{"issue":"4","key":"e_1_2_10_14_1","first-page":"117","article-title":"Identification and Ethnobotanical Survey of Profitable Medicinal Plants Used as Remedy in Sangina Pakistan","volume":"5","author":"Hassan N.","year":"2017","journal-title":"International Journal of Herbal Medicine"}],"container-title":["Chemistry &amp; 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