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In the present study, nine labdane\u2010type diterpenoids, including four novel (<jats:bold>1<\/jats:bold>\u2013<jats:bold>4<\/jats:bold>) and five known (<jats:bold>5<\/jats:bold>\u2013<jats:bold>9<\/jats:bold>), were isolated and identified from the rhizomes of <jats:italic>A. zerumbet<\/jats:italic>. Anti\u2010neuroinflammatory activities of the isolated labdane\u2010type diterpenoids were evaluated in lipopolysaccharide (LPS)\u2010stimulated microglia BV2 cells. Compounds <jats:bold>3<\/jats:bold>, <jats:bold>5<\/jats:bold>, <jats:bold>6<\/jats:bold>, and <jats:bold>8<\/jats:bold> could significantly inhibit the production of nitric oxide (NO) in LPS\u2010stimulated BV2 cells. Among them, the IC<jats:sub>50<\/jats:sub> values of compounds <jats:bold>5<\/jats:bold> and <jats:bold>8<\/jats:bold> were 26.14\u00a0\u00b1\u00a01.62 and 17.29\u00a0\u00b1\u00a06.28\u00a0\u00b5M, which were lower than that of the positive control, minocycline (IC<jats:sub>50<\/jats:sub>\u00a0=\u00a030.26\u00a0\u00b1\u00a01.99\u00a0\u00b5M).<\/jats:p>","DOI":"10.1002\/cbdv.202500154","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T17:25:21Z","timestamp":1741713921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anti\u2010Neuroinflammatory Labdane Diterpenoids From the Rhizomes of <i>Alpinia zerumbet<\/i>"],"prefix":"10.1002","volume":"22","author":[{"given":"Jinghui","family":"Wu","sequence":"first","affiliation":[{"name":"School of Pharmacy Guangdong Pharmaceutical University Guangzhou China"},{"name":"Guangdong Engineering Research Center for Lead Compounds &amp; Drug Discovery Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Guangdong Pharmaceutical University Guangzhou China"},{"name":"Guangdong Engineering Research Center for Lead Compounds &amp; 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