{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:05:32Z","timestamp":1773014732970,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Our previous research has confirmed that the\n                    <jats:italic>Leptopus<\/jats:italic>\n                    genus plants possess significant anti\u2010tumor and hepatoprotective effects, and over 50 triterpenoids were isolated from these plants. In the present work, the anti\u2010inflammatory activities of four\n                    <jats:italic>Leptopus<\/jats:italic>\n                    genus plants were evaluated before phytochemical experiments. Subsequently, eight flavonoids (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>8<\/jats:bold>\n                    ) including two previously undescribed prenylated flavonoids (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>2<\/jats:bold>\n                    ) were isolated from the whole plants of\n                    <jats:italic>Leptopus clarkei<\/jats:italic>\n                    . The structures of these new compounds were unequivocally elucidated by high\u2010resolution electrospray ionization mass spectrometry and one\u2010\/two\u2010dimensional nuclear magnetic resonance data. Additionally, all isolates were evaluated for their anti\u2010inflammatory activities. Among these compounds,\n                    <jats:bold>1<\/jats:bold>\n                    exhibited moderate anti\u2010inflammatory activity with a minimum inhibitory concentration value of 26.5 \u00b1\u00a01.2 \u00b5M on nitric oxide production in lipopolysaccharide\u2010induced RAW264.7 cells.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500160","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T23:48:07Z","timestamp":1744069687000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Flavonoids From the Whole Plants of\n                    <i>Leptopus clarkei<\/i>\n                    and Their In Vitro Anti\u2010inflammatory Activities"],"prefix":"10.1002","volume":"22","author":[{"given":"Xin\u2010Yu","family":"Meng","sequence":"first","affiliation":[{"name":"Medical Research Center Binzhou Medical University Hospital  Binzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo\u2010Wei","family":"Cai","sequence":"additional","affiliation":[{"name":"National Drug Clinical Experimental Organization Binzhou Medical University Hospital  Binzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Miao","sequence":"additional","affiliation":[{"name":"Medical Research Center Binzhou Medical University Hospital  Binzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Yuan","family":"Lv","sequence":"additional","affiliation":[{"name":"Medical Research Center Binzhou Medical University Hospital  Binzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si\u2010Qi","family":"Ren","sequence":"additional","affiliation":[{"name":"Medical Research Center Binzhou Medical University Hospital  Binzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Juan","family":"Yang","sequence":"additional","affiliation":[{"name":"Medical Research Center Binzhou Medical University Hospital  Binzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai\u2010Kai","family":"Gong","sequence":"additional","affiliation":[{"name":"Medical Research Center Binzhou Medical University Hospital  Binzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7956-712X","authenticated-orcid":false,"given":"Shi\u2010Zhou","family":"Qi","sequence":"additional","affiliation":[{"name":"National Drug Clinical Experimental Organization Binzhou Medical University Hospital  Binzhou China"},{"name":"Department of Pharmacy Binzhou Medical University Hospital  Binzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Flora of China","author":"Editor Committee for Flora of China of Chinese Academy of Science","year":"1994"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12225-009-9155-x"},{"key":"e_1_2_9_4_1","volume-title":"Xinhua Bencao Gangyao","author":"Wu Z. 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