{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:05:06Z","timestamp":1773493506567,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001410","name":"Human Resource Development Group","doi-asserted-by":"publisher","award":["788\/ (CSIR\u2010UGC NET DEC. 2018"],"award-info":[{"award-number":["788\/ (CSIR\u2010UGC NET DEC. 2018"]}],"id":[{"id":"10.13039\/501100001410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Diabetic people face a higher risk of developing certain types of cancers. Humans have used plants to treat each of these diseases but a combined remedy still eludes us.\n                    <jats:italic>Hydnocarpus pentandrus<\/jats:italic>\n                    (Buch.\u2013Ham.) Oken is an under\u2010studied endemic plant of India. We evaluated the antioxidant, anti\u2010proliferative and porcine pancreatic \u03b1\u2010amylase (PPA) inhibitory properties of methanol extract of\n                    <jats:italic>H. pentandrus<\/jats:italic>\n                    leaves (CHM). CHM contained various secondary metabolites, and 22 active compounds, mostly flavonoids, were detected with LC\u2013MS\/MS. This is the first report of presence of rutin, vitexin and luteolin in leaves of\n                    <jats:italic>H. pentandrus<\/jats:italic>\n                    . CHM and rutin and vitexin standards exhibited significant free radical scavenging potential. The anti\u2010proliferative potential of the CHM (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a0326.29\u00a0\u00b5g\/mL), rutin (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a058.87\u00a0\u00b5g\/mL) and vitexin (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a064.35\u00a0\u00b5g\/mL) was estimated with MTT assay in MDA\u2010MB\u2010231 cells in vitro. Apoptosis\u2010related activity of the same samples was confirmed with DAPI staining. CHM, rutin and vitexin also showed dose\u2010dependent inhibition of PPA. During in silico docking studies, both rutin and vitexin exhibited a strong binding affinity for PPA and phosphoinositide 3\u2010kinase (PI3K) proteins. Thus, the observed biological activities of CHM extract could be due to rutin and vitexin, the two most abundant flavonoids.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500163","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T20:41:16Z","timestamp":1757709676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antioxidant, Anti\u2010Proliferative and Porcine \u03b1\u2010Amylase Inhibitory Potential of Flavonoids From\n                    <i>Hydnocarpus pentandrus<\/i>\n                    (Buch.\u2013Ham.) Oken (In Vitro and In Silico Studies)"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3814-9449","authenticated-orcid":false,"given":"Mugdha G.","family":"Juwale","sequence":"first","affiliation":[{"name":"Department of Botany Savitribai Phule Pune University  Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2878-0837","authenticated-orcid":false,"given":"Anuja D.","family":"Kamble","sequence":"additional","affiliation":[{"name":"Department of Botany Savitribai Phule Pune University  Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitendra","family":"Munot","sequence":"additional","affiliation":[{"name":"Octarine Organics  Navi Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1847-8646","authenticated-orcid":false,"given":"Anjali A.","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Department of Botany Savitribai Phule Pune University  Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf021150r"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040262"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12207"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbi\/wbaa110"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2020.5135"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2017.07.013"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/20503121211034366"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12068"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.615375"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.13909"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/boj.12385"},{"key":"e_1_2_8_13_1","first-page":"4349","article-title":"HPTLC Studies on the Leaf Extract of Hydnocarpus pentandra (Buch.\u2010Ham.) 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