{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:16:08Z","timestamp":1792001768075,"version":"4.4.0"},"reference-count":226,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry & Biodiversity"],"abstract":"ABSTRACT<\/jats:title>Neurodegenerative diseases (NDs) exhibit significant global public health challenges due to the lack of effective treatments. Berberine (BBR), a natural alkaloid compound in various plants, has been recognized for its potential neuroprotective properties. This review explores the current understanding of BBR's mechanisms of action and its therapeutic potential in preventing and treating NDs such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. BBR's neuroprotective properties are attributed to its multifaceted actions, including anti\u2010inflammatory, antioxidant, antiapoptotic, and neurotrophic effects. In addition, BBR can influence many signaling pathways involved in neurodegeneration, including AMP\u2010activated protein kinase (AMPK), nuclear factor erythroid 2\u2010related factor 2, and brain\u2010derived neurotrophic factor pathways. Furthermore, BBR targets vital signaling pathways, including AMPK, PI3K\/Akt, and MAPK, which are essential for developing NDs. In addition, BBR's efficacy in reducing neurodegenerative pathology and improving cognitive function has been demonstrated through preclinical studies using cellular and animal models. Clinical trials demonstrating BBR's therapeutic potential in NDs have yielded promising results, but further research is needed to confirm its safety and efficacy in humans.<\/jats:p>","DOI":"10.1002\/cbdv.202500170","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T03:19:57Z","timestamp":1742872797000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Unraveling Berberine's Molecular Mechanisms in Neuroprotection Against Neurodegeneration"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6512-3872","authenticated-orcid":false,"given":"Md. Zamshed Alam","family":"Begh","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Health and Life Sciences Daffodil International University Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Al","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Health and Life Sciences Daffodil International University Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mst Maharunnasa","family":"Shatu","sequence":"additional","affiliation":[{"name":"Department of Botany Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherouk Hussein","family":"Sweilam","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy College of Pharmacy, Prince Sattam Bin Abdulaziz University Al\u2010Kharj Saudi Arabia"},{"name":"Department of Pharmacognosy, Faculty of Pharmacy Egyptian Russian University Badr City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Puri","sequence":"additional","affiliation":[{"name":"School of Pharmacy & Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Deemed\u2010to\u2010University Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rathod Bhagyashri","family":"Ramesh","sequence":"additional","affiliation":[{"name":"School of Pharmacy & Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Deemed\u2010to\u2010University Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uppuluri Varuna Naga Venkata","family":"Arjun","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS) Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thukani Sathanantham","family":"Shanmugarajan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS) Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagaveni","family":"Pommala","sequence":"additional","affiliation":[{"name":"S. V. U. College of Pharmaceutical Sciences, Sri Venkateswara University Tirupati India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiladevi","family":"Durairaj","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS) Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susithra","family":"Ethiraj","sequence":"additional","affiliation":[{"name":"S. V. U. 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