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The current research aimed to determine the phytochemical compounds and to explore the antihyperglycemic effects of <jats:italic>C<\/jats:italic>. <jats:italic>angustifolia<\/jats:italic> leaves through in vitro and in silico methods. The phytochemicals in the methanolic extract of leaves of <jats:italic>C<\/jats:italic>. <jats:italic>angustifolia<\/jats:italic> were detected using Fourier\u2010transform infrared, gas chromatography\u2013mass spectrometry and liquid chromatography\u2013mass spectrometry techniques. The antihyperglycemic potential of the different solvent extracts was evaluated using in vitro assays. The methanolic extract demonstrated comparatively higher inhibitory effects on both <jats:italic>\u03b1<\/jats:italic>\u2010amylase and <jats:italic>\u03b1<\/jats:italic>\u2010glucosidase enzymes, with the effects varying according to the concentration, and the half maximal inhibitory concentration values were 592.57\u00a0\u00b1\u00a00.64 and 267.11\u00a0\u00b1\u00a00.82\u00a0\u00b5g\/ml, respectively. 2\u2010<jats:italic>p<\/jats:italic>\u2010Nitrophenyl\u2010oxadiazol\u20101,3,4\u2010one\u20105 was identified as a potential compound that could exhibit antihyperglycemic effects via molecular docking. 2\u2010<jats:italic>p<\/jats:italic>\u2010Nitrophenyl\u2010oxadiazol\u20101,3,4\u2010one\u20105 was found to have optimal physicochemical characteristics needed for drug\u2010likeness based on in silico absorption, distribution, metabolism, excretion, and toxicity assessment. The prediction of activity spectra for substances prediction findings suggested that 2\u2010<jats:italic>p<\/jats:italic>\u2010nitrophenyl\u2010oxadiazol\u20101,3,4\u2010one\u20105 displays potent anti\u2010diabetic activity, which aligns with the docking results. The findings suggested that the methanol extract of the leaves of <jats:italic>C<\/jats:italic>. <jats:italic>angustifolia<\/jats:italic> exhibits notable antihyperglycemic properties. Therefore, it could also be investigated to purify the active compound with antihyperglycemic effects.<\/jats:p>","DOI":"10.1002\/cbdv.202500173","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T21:33:33Z","timestamp":1748381613000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phytochemical Composition and Inhibitory Effects of <i>Curcuma angustifolia<\/i> Leaves Extracts Against <i>\u03b1<\/i>\u2010Amylase and <i>\u03b1<\/i>\u2010Glucosidase Enzymes Associated With Hyperglycaemia: In Vitro and In Silico Analysis"],"prefix":"10.1002","author":[{"given":"P.","family":"Kavya","sequence":"first","affiliation":[{"name":"Department of Bio Medical Sciences, School of Bio Sciences and Technology Vellore Institute of Technology  Vellore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1087-2748","authenticated-orcid":false,"given":"M.","family":"Gayathri","sequence":"additional","affiliation":[{"name":"Department of Bio Medical Sciences, School of Bio Sciences and Technology Vellore Institute of Technology  Vellore India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1016\/j.jep.2020.113739"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1016\/j.jep.2021.113781"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13568-021-01219-3","article-title":"An Endophytic Schizophyllum commune Fr. exhibits In\u2010Vitro and In\u2010Vivo Antidiabetic Activity in Streptozotocin Induced Diabetic Rats","volume":"11","author":"Sharma A.","year":"2021","journal-title":"AMB Express"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.3390\/foods10020315"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.1016\/j.biopha.2018.07.157"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.1155\/2022\/1531289"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","DOI":"10.1177\/11786388221118875","article-title":"Effectiveness of 3 Polyherbal Formulations (EcXaPu, EcXa, and EcPu) on the Management of Oxidative Stress and Hyperglycemia","volume":"15","author":"Essola N. 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