{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:07:46Z","timestamp":1787652466155,"version":"build-2736575974"},"reference-count":70,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Cancer remains a leading cause of mortality, and medicinal plants offer potential anticancer agents due to their biological activities and minimal side effects. <jats:italic>Lavandula stoechas<\/jats:italic> L., a Mediterranean species, shows significant pharmacological potential. This study evaluated the composition, antioxidant, and antiproliferative properties of <jats:italic>L. stoechas<\/jats:italic> aqueous, methanol (MeOH), ethanol (EtOH), ethyl acetate, and chloroform extracts from a naturalized plant in Jordan. The aroma profile and composition of the hydro\u2010distilled essential oil were also determined. Gas chromatography (GC) and GC\u2010mass spectrometry (GC\u2010MS) analysis identified fenchone, camphor, \u03b1\u2010pinene and borneol as major constituents, with solid\u2010phase microextraction revealing fenchone and \u03b1\u2010thujene as dominant volatile compounds. Phytochemical analysis showed the EtOH extract had the highest total phenolic content (147.60 \u00b1 31.80\u00a0mg\/g) and total flavonoid content (84.56 \u00b1 4.33\u00a0mg\/g), while the MeOH extract exhibited the strongest antioxidant activity (409.83 \u00b1 3.13\u00a0\u00b5M TE\/g). The EtOH extract displayed cytotoxic activity with IC<jats:sub>50<\/jats:sub> values ranging from 22.79 to 94.06\u00a0\u00b5g\/mL against various cancer cell lines. Liquid chromatography\u2010MS analysis identified rosmarinic acid as the most abundant compound (28.71%), which may contribute to the biological activity. This study highlights the potent antioxidant and antiproliferative properties of <jats:italic>L. stoechas<\/jats:italic>, especially the EtOH extract.<\/jats:p>","DOI":"10.1002\/cbdv.202500181","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T16:50:15Z","timestamp":1743526215000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Phytochemistry and Antiproliferative Potential of a Naturalized Plant in Jordan: <i>Lavandula stoechas<\/i>"],"prefix":"10.1002","author":[{"given":"Heba","family":"Syaj","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences Faculty of Pharmacy Al\u2010Zaytoonah University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nour","family":"Aboalhaija","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Faculty of Pharmacy Al\u2010Zaytoonah University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Afifi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences School of Pharmacy The University of Jordan, Queen Rania Al Abdallah Street  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Abu\u2010Dahab","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Pharmaceutical Technology School of Pharmacy The University of Jordan, Queen Rania Al Abdallah Street  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samah","family":"Abusulieh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Faculty of Pharmacy Al\u2010Zaytoonah University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razan","family":"Amro","sequence":"additional","affiliation":[{"name":"Department of Chemistry School of Science The University of Jordan, Queen Rania Al Abdallah Street  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2019.120251","article-title":"Electrochemical Biosensors for the Detection of Lung Cancer Biomarkers: A Review","volume":"206","author":"Khanmohammadi A.","year":"2020","journal-title":"Talanta"},{"issue":"3","key":"e_1_2_7_3_1","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung H.","year":"2021","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.2147\/DDDT.S379496","article-title":"Recent Updates on the Development of Deuterium\u2010containing Drugs for the Treatment of Cancer","volume":"1","author":"Belete T. 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