{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:16:38Z","timestamp":1784114198368,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Despite advancements in drug delivery, breast cancer remains a leading cause of mortality, and creating therapeutic systems that balance efficacy and safety remains a challenge. Selenium (Se) and curcumin (Cur) exhibit antioxidant and anticancer properties, but their efficient application in cancer therapy is complex. This study developed a targeted drug delivery system for 4T1 breast cancer cells using selenium nanoparticles (SeNPs) loaded with curcumin and coated with chitosan\u2010folic acid (Cs\u2010FA) to enhance targeting efficiency. The incorporation of Cs\u2010FA and Cur increased nanoparticle size from 105 to 184.2\u00a0nm and reduced 4T1 cell viability by 40% at a concentration of 40\u00a0\u00b5g\/mL. The Cs\u2010FA coating significantly enhanced apoptosis, as evidenced by upregulated p53 and downregulated BCL2 gene expression compared to other formulations. These results suggest that Se@Cur\/Cs\u2010FA nanoparticles effectively induce apoptosis, highlighting their potential as a promising cancer therapy.<\/jats:p>","DOI":"10.1002\/cbdv.202500183","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T16:12:13Z","timestamp":1750090333000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Folic Acid Targeted Selenium\u2013Curcumin Nanoparticles to Enhance Apoptosis in Breast Cancer Cells"],"prefix":"10.1002","author":[{"given":"Fateme","family":"Davarani Asl","sequence":"first","affiliation":[{"name":"Student Research Committee Shahrekord University of Medical Sciences  Shahrekord Iran"},{"name":"Department of Medical Biotechnology School of Advanced Technologies Shahrekord University of Medical Sciences  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooria","family":"Mohammadi Arvejeh","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center Basic Health Sciences Institute Shahrekord University of Medical Sciences  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Rezaee","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology School of Advanced Technologies Shahrekord University of Medical Sciences  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Saffari\u2010Chaleshtori","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Research Center Basic Health Sciences Institute Shahrekord University of Medical Sciences  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Deris","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology Health Faculty Shahrekord University of Medical Sciences  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atefeh","family":"Satari","sequence":"additional","affiliation":[{"name":"Student Research Committee Shahrekord University of Medical Sciences  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Asgharzadeh","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology School of Advanced Technologies Shahrekord University of Medical Sciences  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4802-8534","authenticated-orcid":false,"given":"Pegah","family":"Khosravian","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center Basic Health Sciences Institute Shahrekord University of Medical Sciences  Shahrekord Iran"},{"name":"Medical Plants Research Center Basic Health Sciences Institute Shahrekord University of Medical Sciences  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.7326\/M20-6348","article-title":"Measuring Pandemic Impact: Vital Signs From Vital Statistics","volume":"173","author":"Gerberding J. 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