{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:29:52Z","timestamp":1787498992960,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Raspberry ketone is an aromatic phenolic natural product with a variety of bioactivities. To discover novel fungicide molecules based on raspberry ketone, a total of 25 raspberry ketone ester derivatives were synthesized, and their chemical structures were well characterized. Among them, most compounds have not been reported except for compounds\n                    <jats:bold>3a<\/jats:bold>\n                    and\n                    <jats:bold>3n<\/jats:bold>\n                    . Compound\n                    <jats:bold>3f<\/jats:bold>\n                    exhibited the most significant antifungal activity against\n                    <jats:italic>Valsa mali<\/jats:italic>\n                    with the EC\n                    <jats:sub>50<\/jats:sub>\n                    of 16.430 \u00b5M, indicating that its antifungal activity was 234.6 folds more potent than that of raspberry ketone (EC\n                    <jats:sub>50<\/jats:sub>\n                    : 3854.401 \u00b5M). Compounds\n                    <jats:bold>3c<\/jats:bold>\n                    and\n                    <jats:bold>3j<\/jats:bold>\n                    displayed the broad\u2010spectrum antifungal activity against three phytopathogenic fungi, which can be further optimized as the secondary lead compounds for the discovery of novel fungicide molecules. The structure\u2010antifungal activity relationships indicated that acylation of the hydroxy group in the molecule of raspberry ketone could significantly improve its antifungal activity and the two methylene in the bridging chain is essential for its antifungal activity. This work will provide some reference for the development of novel fungicide candidates based on the natural product raspberry ketone.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500187","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T19:40:31Z","timestamp":1745696431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synthesis and Antifungal Activity of Raspberry Ketone Ester Derivatives as Potential Fungicides"],"prefix":"10.1002","volume":"22","author":[{"given":"Lili","family":"Shu","sequence":"first","affiliation":[{"name":"College of Horticulture and Plant Protection Henan University of Science and Technology Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyang","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Horticulture and Plant Protection Henan University of Science and Technology Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqin","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Horticulture and Plant Protection Henan University of Science and Technology Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongtai","family":"Li","sequence":"additional","affiliation":[{"name":"College of Horticulture and Plant Protection Henan University of Science and Technology Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Horticulture and Plant Protection Henan University of Science and Technology Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuee","family":"Tian","sequence":"additional","affiliation":[{"name":"College of Horticulture and Plant Protection Henan University of Science and Technology Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Qian","sequence":"additional","affiliation":[{"name":"College of Horticulture and Plant Protection Henan University of Science and Technology Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genqiang","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Horticulture and Plant Protection Henan University of Science and Technology Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengming","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Horticulture and Plant Protection Henan University of Science and Technology Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6211-9531","authenticated-orcid":false,"given":"Xiaobo","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Horticulture and Plant Protection Henan University of Science and Technology Luoyang China"},{"name":"Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science China Agricultural University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Hao","sequence":"additional","affiliation":[{"name":"College of Horticulture and Plant Protection Henan University of Science and Technology Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Che","sequence":"additional","affiliation":[{"name":"College of Horticulture and Plant Protection Henan University of Science and Technology Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.670135"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094658"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42483-022-00142-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-phyto-080615-095919"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42483-023-00200-1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10947"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.6653"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c02293"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c07423"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ffj.3678"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants10071323"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202400090"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10030482"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jen.12952"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12020239"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2016.08.020"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/1386207324666210813114829"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202100329"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.6985"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2023.135260"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1094\/PHYTO-10-22-0370-KD"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.01.024"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1081\/SCC-120016367"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202401348"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202500187","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202500187","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202500187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:56:25Z","timestamp":1773010585000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202500187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,26]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/cbdv.202500187"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202500187","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,26]]},"assertion":[{"value":"2025-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202500187"}}