{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T19:08:58Z","timestamp":1775070538649,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This research delved into the effects and mechanisms of total flavonoids of <jats:italic>Engelhardia roxburghiana<\/jats:italic> Wall. (TFER) on nonalcoholic fatty liver disease (NAFLD). High\u2010fat diet\u2010induced NAFLD rat models and palmitic acid\u2010induced HepG2 cell models were employed. In both models, TFER significantly reduced serum levels of triglycerides (TG), total cholesterol (TC), aspartate aminotransferase (AST), alanine aminotransferase (ALT), malondialdehyde (MDA), and inflammatory factors such as interleukin\u20106 (IL\u20106), interleukin 1 beta (IL\u20101\u03b2), and tumor necrosis factor\u2010alpha (TNF\u2010\u03b1). Additionally, it increased superoxide dismutase (SOD) levels. Mechanistically, TFER regulated lipid\u2010related proteins Sterol Regulatory Element\u2010Binding Protein 1 (SREBP1), peroxisome proliferator\u2010activated receptor alpha (PPAR\u03b1), and Retinol Binding Protein 4 (RBP4). In summary, TFER exhibits potential for treating NAFLD by modulating these lipid\u2010related proteins.<\/jats:p>","DOI":"10.1002\/cbdv.202500190","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T19:44:18Z","timestamp":1749584658000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Total Flavonoids of <i>Engelhardia roxburghiana<\/i> Wall. Attenuated Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism and Inflammation Through Targeting SREBP1 and PPAR\u03b1"],"prefix":"10.1002","author":[{"given":"Qiuyan","family":"Huang","sequence":"first","affiliation":[{"name":"Center for Pharmacodynamics and Safety Evaluation of Chinese Materia Medica Guangxi Institute of Chinese Medicine &amp; Pharmaceutical Science  Nanning P. R. 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