{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T11:49:14Z","timestamp":1775476154949,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Trema micranthum<\/jats:italic> (L.) Blume is a species from the Cannabaceae botanical family, present all over the tropics. A recent study conducted by our group identified the presence of cannabidiol (CBD), \u0394<jats:sup>9<\/jats:sup>\u2010tetrahydrocannabinol, cannabidiolic acid, and tetrahydrocannabinolic acid\u2010A in <jats:italic>T. micranthum<\/jats:italic> extracts. Their presence in the plant's fruit, inflorescence, and leaf extracts was detected and quantified. <jats:italic>T. micranthum<\/jats:italic> has been identified as a potential new source of cannabinoids such as CBD. The present work focuses on a new Cannabinoid Profiling System (CPS) to present a wide view of cannabinoid chemical composition with several compassionate and modern mass spectrometry (MS) tools. Extracts from fruits, leaves, and inflorescences were obtained using a methanol\/hexane (9:1, v\/v) solvent mixture. Ultra high\u2010performance liquid chromatography coupled with high\u2010resolution tandem MS using targeted and untargeted approaches were used in these approaches. CPS allowed the identification of the 26 cannabinoids in <jats:italic>T. micranthum<\/jats:italic> described for the first time in this plant.<\/jats:p>","DOI":"10.1002\/cbdv.202500208","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T20:39:04Z","timestamp":1747946344000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cannabinoids From <i>Trema micranthum<\/i> (L.) Blume (Cannabaceae): A Cannabinoid Profiling System"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9486-7722","authenticated-orcid":false,"given":"Yasmin","family":"Cunha\u2010Silva","sequence":"first","affiliation":[{"name":"Chemical Engineering Section Military Institute of Engineering  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6533-3530","authenticated-orcid":false,"given":"Rayssa","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Chemical Engineering Section Military Institute of Engineering  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Finotti","sequence":"additional","affiliation":[{"name":"Department of Biology Est\u00e1cio de S\u00e1 University  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1299-4121","authenticated-orcid":false,"given":"Gabriel Reis","family":"Alves Carneiro","sequence":"additional","affiliation":[{"name":"Federal University of Rio de Janeiro, Chemistry Institute, Brazilian Doping Control Laboratory  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0943-7255","authenticated-orcid":false,"given":"Gustavo Ramalho Cardoso","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Federal University of Rio de Janeiro, Chemistry Institute, Brazilian Doping Control Laboratory  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8597-416X","authenticated-orcid":false,"given":"Henrique Marcelo Gualberto","family":"Pereira","sequence":"additional","affiliation":[{"name":"Federal University of Rio de Janeiro, Chemistry Institute, Brazilian Doping Control Laboratory  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3760-8231","authenticated-orcid":false,"given":"Monica Costa","family":"Padilha","sequence":"additional","affiliation":[{"name":"Federal University of Rio de Janeiro, Chemistry Institute, Brazilian Doping Control Laboratory  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1365-7602","authenticated-orcid":false,"given":"Valdir Flor\u00eancio","family":"Veiga\u2010Junior","sequence":"additional","affiliation":[{"name":"Chemical Engineering Section Military Institute of Engineering  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13361-019-02164-z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2019.01.032"},{"key":"e_1_2_9_4_1","first-page":"90","article-title":"Cannabinoids Quantification in Medicinal Cannabis Extracts by High Performance Liquid Chromatography","volume":"43","author":"Carvalho V. 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