{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:18:32Z","timestamp":1789705112726,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>To find efficient insecticides with novel structures, 16 novel <jats:italic>m<\/jats:italic>\u2010diamide compounds containing sulfur were designed and synthesized based on the principle of biologically active factor splicing with cyproflanilide as the lead compound. Preliminary biological assay data showed that some of the target compounds exhibited insecticidal activity above 90% against <jats:italic>Mythimna separata<\/jats:italic> at 0.01\u00a0mg\/L and <jats:italic>Aphis craccivora<\/jats:italic> at 100\u00a0mg\/L, which were better than cyproflanilide. Meanwhile, most compounds still maintain 100% mortality at 1\u00a0mg\/L for <jats:italic>Plutella xylostella<\/jats:italic>. In particular, compounds <jats:bold>5c<\/jats:bold>, <jats:bold>5e<\/jats:bold>, <jats:bold>5f<\/jats:bold>, and <jats:bold>5g<\/jats:bold> revealed excellent activities against <jats:italic>P. xylostella<\/jats:italic>, <jats:italic>M. separata<\/jats:italic>, and <jats:italic>A. craccivora<\/jats:italic>, exhibiting efficient and broad\u2010spectrum insecticidal activity. Additionally, the interaction between the metabolites of cyproflanilide, compound <jats:bold>5g<\/jats:bold>, and \u03b3\u2010aminobutyric acid receptor protein was studied by molecular docking method. The results showed that they could be stably bound to the potential active cavity in the protein to form a protein\u2010ligand complex, thus showing excellent insecticidal activity, which is consistent with the data on the excellent insecticidal activity of compounds. This work showed that sulfur\u2010containing compounds might provide certain clues for structure optimization for the development of new insecticides.<\/jats:p>","DOI":"10.1002\/cbdv.202500230","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T01:08:58Z","timestamp":1742951338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Design, Synthesis, and Insecticidal Activity of Novel <i>m<\/i>\u2010Diamide Compounds Containing Sulfur"],"prefix":"10.1002","author":[{"given":"Pengmian","family":"Huang","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Changsha University of Science and Technology  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualan","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Changsha University of Science and Technology  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Wu","sequence":"additional","affiliation":[{"name":"CAC Nantong Chemical Co., Ltd.  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqi","family":"Zhou","sequence":"additional","affiliation":[{"name":"CAC Nantong Chemical Co., Ltd.  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Huang","sequence":"additional","affiliation":[{"name":"CAC Nantong Chemical Co., Ltd.  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5832-998X","authenticated-orcid":false,"given":"Jiyong","family":"Liu","sequence":"additional","affiliation":[{"name":"CAC Nantong Chemical Co., Ltd.  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