{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T23:27:14Z","timestamp":1784330834571,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The overuse of antibiotics is one of the reasons which has led to the development of drug\u2010resistant bacteria, which is a huge challenge for modern medicine. As well as the incidences of cancer, which are increasing every year, currently known cytostatics do not provide satisfactory therapeutic effects with many side effects. Bearing in mind these problems of modern medicine, we have synthesized new acylhydrazones with potential antibacterial and anticancer activities. The compounds were created as a result of condensation of commercially available nicotinic acid hydrazide with appropriate aldehydes. Additionally, some of them were obtained using mechanochemistry. The chemical structure of the obtained compounds was confirmed by spectral methods IR, <jats:sup>1<\/jats:sup>H NMR and <jats:sup>13<\/jats:sup>C NMR, and the crystal structure of selected compounds was determined by single\u2010crystal X\u2010ray diffraction analysis. Phase purity tests were performed for each compound. The tested compounds had very significant activity against Gram\u2010positive bacteria and slightly worse activity against fungi from the genus <jats:italic>Candida<\/jats:italic>. The least antibacterial activity of obtained acylhydrazones was shown against Gram\u2010negative bacterial strains. In addition to these, the compounds described did not have a toxic effect on normal cell lines.<\/jats:p>","DOI":"10.1002\/cbdv.202500264","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T15:58:31Z","timestamp":1743523111000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Novel Derivatives of Nicotinic Acid: Synthesis, Crystal Structure, Antimicrobial Activity and Cytotoxicity"],"prefix":"10.1002","author":[{"given":"Izabela","family":"Czy\u017cewska","sequence":"first","affiliation":[{"name":"Chair and Department of Organic Chemistry Faculty of Pharmacy Medical University of Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Mazur","sequence":"additional","affiliation":[{"name":"Institute of Chemical Sciences Faculty of Chemistry Maria Curie\u2010Sk\u0142odowska University  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Biernasiuk","sequence":"additional","affiliation":[{"name":"Chair and Department of Pharmaceutical Microbiology Faculty of Pharmacy Medical University of Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Hordyjewska","sequence":"additional","affiliation":[{"name":"Chair and Department of Medicinal Chemistry Faculty of Medical Sciences Medical University of Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Popio\u0142ek","sequence":"additional","affiliation":[{"name":"Chair and Department of Organic Chemistry Faculty of Pharmacy Medical University of Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00389-17"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00239\u2010019\u201009914\u20103"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.1c07981"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2cs00997h"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.202100478"},{"key":"e_1_2_7_7_1","volume-title":"Green Chemistry: Theory and Practice","author":"Anastas P. T.","year":"1998"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e05019"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2006.08.022"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044\u2010016\u20101756\u2010y"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179389"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242417481"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113302"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.07.022"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2016.06.022"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2003.08.004"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(02)00071-8"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb\u20102019\u20100085"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm2003624"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.5599\/admet.1179"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23052823"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.13158"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010019\u20100226\u20109"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29163814"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0036023622050151"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1107\/S1600536810006276"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/cg401866x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.5b01673"},{"key":"e_1_2_7_29_1","volume-title":"Software System","author":"CrysAlisPRO","year":"2016"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1107\/s2053273314026370"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2053229614024218"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1107\/S1600576719014092"},{"key":"e_1_2_7_33_1","volume-title":"HighScore Plus, Software Ver. 3.0.5","author":"PANalytical","year":"2012"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2003.00790.x"},{"key":"e_1_2_7_35_1","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts. M27\u2010S4","author":"Clinical and Laboratory Standards Institute","year":"2012"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/10426507.2014.919293"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.521"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2009.06.031"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202500264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T20:59:10Z","timestamp":1746478750000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202500264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,5]]},"references-count":37,"alternative-id":["10.1002\/cbdv.202500264"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202500264","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,5]]},"assertion":[{"value":"2025-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202500264"}}