{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T15:19:31Z","timestamp":1768922371467,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Sphaerocoryne affinis<\/jats:italic> is traditionally utilized in Vietnam for the production of alcoholic beverages. This study represented the first comprehensive investigation into the phytochemical profile and anti\u2010inflammatory properties of <jats:italic>S. affinis<\/jats:italic> fruit. Using the RAW264.7 macrophage model stimulated by lipopolysaccharide, this study demonstrated the anti\u2010inflammatory potential of <jats:italic>S. affinis<\/jats:italic> fruit ethanol extract, primarily through nitric oxide (NO) inhibition. The results revealed that ethyl acetate fraction exhibited the strongest inhibitory effect on both NO radicals and NO production. Furthermore, thirteen compounds were successfully isolated, including chrysin (<jats:bold>1<\/jats:bold>), (5Z,7R)\u2010acetyl melodorinol (<jats:bold>2<\/jats:bold>), daucosterol (<jats:bold>3<\/jats:bold>), pinocembrin (<jats:bold>4<\/jats:bold>), naringenin (<jats:bold>5<\/jats:bold>), melodorinol (<jats:bold>6<\/jats:bold>), (4Z)\u20105\u2010(2,3\u2010dihydroxy\u2010propylidene)\u20105H\u2010furan\u20102\u2010one (<jats:bold>7<\/jats:bold>), (\u2212)\u2010malic acid (<jats:bold>8<\/jats:bold>), (E)\u20103\u2010(furan\u20102\u2010yl)acrylic acid (<jats:bold>9<\/jats:bold>), p\u2010coumaric acid (<jats:bold>10<\/jats:bold>), caffeic acid (<jats:bold>11<\/jats:bold>), chlorogenic acid (<jats:bold>12<\/jats:bold>), and 5\u2010O\u2010(E)\u2010<jats:italic>p<\/jats:italic>\u2010coumaroylquinic acid methyl ester (<jats:bold>13<\/jats:bold>). Among these, seven compounds (<jats:bold>5<\/jats:bold>, <jats:bold>8<\/jats:bold>, <jats:bold>9<\/jats:bold>, <jats:bold>10<\/jats:bold>, <jats:bold>11<\/jats:bold>, and <jats:bold>13<\/jats:bold>) were identified for the first time in this species, offering significant insight into its phytochemical profile and therapeutic potential.<\/jats:p>","DOI":"10.1002\/cbdv.202500267","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T15:22:05Z","timestamp":1744039325000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anti\u2010inflammatory Activity and Chemical Composition of <i>Sphaerocoryne affinis<\/i> Fruit in Phu Quoc Island"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9682-9240","authenticated-orcid":false,"given":"Huynh Kim","family":"Yen","sequence":"first","affiliation":[{"name":"Department of Biotechnology, College of Food Science and Health Kien Giang University  Kien Giang Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2132-113X","authenticated-orcid":false,"given":"Nguyen Quoc Chau","family":"Thanh","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Natural Sciences Can Tho University  Can Tho Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6197-8846","authenticated-orcid":false,"given":"Truong Thi Tu","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, College of Food Science and Health Kien Giang University  Kien Giang Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5128-4654","authenticated-orcid":false,"given":"Nguyen Trong","family":"Tuan","sequence":"additional","affiliation":[{"name":"Department of Heath Sciences, College of Natural Sciences Can Tho University  Can Tho Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"issue":"2","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2174\/1871523014666150514102027","article-title":"An Update on Anti\u2010inflammatory Compounds: A Review","volume":"14","author":"Kumar Dhingra A.","year":"2015","journal-title":"Anti\u2010Inflammatory & Anti\u2010Allergy Agents in Medicinal Chemistry"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.12688\/f1000research.51270.2","article-title":"Nitric Oxide for the Prevention and Treatment of\u00a0Viral, Bacterial,\u00a0Protozoal\u00a0and\u00a0Fungal\u00a0Infections","volume":"10","author":"Bath P. 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