{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:11:08Z","timestamp":1784902268691,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry & Biodiversity"],"abstract":"ABSTRACT<\/jats:title>Pesticides that act on unique targets are favored in pesticide research because of their unique mechanism of action and lower proneness to developing cross\u2010resistance. In the previous work, the natural product cingulin V, which was isolated from Celastrus angulatus<\/jats:italic> Maxim in our laboratory, was determined to act on the subunit H on V\u2010ATPase. After homology modeling and virtual docking of the subunit H on V\u2010ATPase, the highest scoring compound was selected for structural modification; two critical functional groups\u2014the sulfonamide and propargyloxy moieties\u2014were ultimately identified as being essential for the significant enhancement of insecticidal activity. On the basis of the previous work, to investigate whether the introduction of oxygen atoms into the sulfonamide structure can enhance the compound's biological activity, we synthesized 25 sulfonamide derivatives and evaluated their insecticidal activity against Mythimna separata<\/jats:italic>. Bioassay results demonstrated that methoxyamine\u2010substituted compounds exhibited significant efficacy at 0.5\u00a0mg\/mL. Notably, compound 5.3<\/jats:bold> showed activity with an LC50<\/jats:sub> of 0.131\u00a0mg\/mL, representing a 200\u2010fold potency enhancement over celangulin V and a 5.26\u2010fold improvement compared to the lead compound. Compound 5.3<\/jats:bold> was verified to act on ATPase as well through symptomological analysis and molecular docking. This study provided potential inhibitors of V\u2010ATPase for the M. separata<\/jats:italic> control.<\/jats:p>","DOI":"10.1002\/cbdv.202500285","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T16:24:37Z","timestamp":1750091077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Design, Synthesis, and Insecticidal Activity of Sulfonamide Structures Containing Methoxyamine as Potential Inhibitors of V\u2010ATPase"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4441-8568","authenticated-orcid":false,"given":"Peixu","family":"Wu","sequence":"first","affiliation":[{"name":"College of Chemistry & Pharmacy Northwest A&F University Xianyang China"},{"name":"Key Laboratory of Botanical Pesticide R&D in Shaanxi Province Xianyang 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Xianyang China"},{"name":"Key Laboratory of Botanical Pesticide R&D in Shaanxi Province Xianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxiu","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry & Pharmacy Northwest A&F University Xianyang China"},{"name":"Key Laboratory of Botanical Pesticide R&D in Shaanxi Province Xianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Chemistry & Pharmacy Northwest A&F University Xianyang China"},{"name":"Key Laboratory of Botanical Pesticide R&D in Shaanxi Province Xianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyu","family":"Ren","sequence":"additional","affiliation":[{"name":"College of Plant Protection Northwest A&F University Xianyang 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