{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:29:01Z","timestamp":1790908141613,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22267022"],"award-info":[{"award-number":["22267022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370423"],"award-info":[{"award-number":["32370423"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Phytochemical investigation of the 80% ethanol extract from the seeds of <jats:italic>Caesalpinia decapetala<\/jats:italic> (Roth) Alston led to the identification of nine compounds, which included three new cassane\u2010type diterpenoids, caesalpideplins A\u2013C (<jats:bold>1\u20133<\/jats:bold>), and six known analogs (<jats:bold>4\u20139<\/jats:bold>). The structures of <jats:bold>1\u20133<\/jats:bold> were determined using a comprehensive analytical method that involved detailed infrared, high\u2010resolution electrospray ionization mass spectrometry studies, as well as proton, carbon\u201013, and two\u2010dimensional nuclear magnetic resonance analyses. The absolute configuration of <jats:bold>1<\/jats:bold> was established through X\u2010ray single crystal diffraction analysis, while the absolute configurations of <jats:bold>2<\/jats:bold> and <jats:bold>3<\/jats:bold> were determined by comparing their calculated and experimental electronic circular dichroism data. Additionally, compounds <jats:bold>3<\/jats:bold>, <jats:bold>4<\/jats:bold>, <jats:bold>5<\/jats:bold>, <jats:bold>7<\/jats:bold>, and <jats:bold>8<\/jats:bold> demonstrated notable inhibitory activity against the Ca<jats:sub>v<\/jats:sub>3.1 T\u2010type calcium channel with half\u2010maximal inhibitory concentration values of 23.13, 9.46, 29.53, 34.02, and 24.33 \u00b5M, respectively. These results suggest that cassane\u2010type diterpenoids may have potential therapeutic applications for diseases related to the Ca<jats:sub>v<\/jats:sub>3.1 calcium channel.<\/jats:p>","DOI":"10.1002\/cbdv.202500298","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T02:56:28Z","timestamp":1740538588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cassan Diterpenoids With Ca<sub>v<\/sub>3.1 T\u2010type Calcium Channel Inhibitory Activity From the Seeds of <i>Caesalpinia decapetala<\/i> (Roth) Alston"],"prefix":"10.1002","volume":"22","author":[{"given":"Chen\u2010Xi","family":"He","sequence":"first","affiliation":[{"name":"School of Pharmacy China Pharmaceutical University  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De\u2010Sheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ethnic Medicine Resource Chemistry Ministry of Education Yunnan Minzu University  Kunming P. R. China"},{"name":"School of Pharmaceutical Science &amp; Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical University  Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ethnic Medicine Resource Chemistry Ministry of Education Yunnan Minzu University  Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu\u2010Dong","family":"Song","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science &amp; Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical University  Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin\u2010Fen","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science &amp; Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical University  Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2526-1269","authenticated-orcid":false,"given":"Xing\u2010De","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ethnic Medicine Resource Chemistry Ministry of Education Yunnan Minzu University  Kunming P. R. 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