{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:17:37Z","timestamp":1778649457527,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007471","name":"Applied Basic Research Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["202407AB110021"],"award-info":[{"award-number":["202407AB110021"]}],"id":[{"id":"10.13039\/100007471","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The formation of boundaries, or inhibition zones, between neighboring colonies is a prevalent phenomenon in nature, occurring not only between different species but also within the same species or even within a single colony. The first work in this series presents extracellular Fenton chemistry as an alternative mechanism for cellular energy production. Specifically, polyketide synthase (PKS)\u2010derived polycyclic aromatic metabolites initiate and amplify robust extracellular Fenton reactions, whereas non\u2010ribosomal peptide synthase (NRPS)\u2010derived siderophores or iron chelators recycle iron and protect the host from the potentially harmful effects of these reactions. Our findings further demonstrate that extracellular Fenton reactions are pivotal in the formation of boundaries, both within and between strains and species. PKS\u2010derived aromatic metabolites promote the establishment of self\u2010inhibition boundaries, while NRPS\u2010derived siderophores primarily alleviate these boundaries. Notably, the development of these boundaries can be modulated by adjusting media components, such as proteins and starch, thereby influencing metabolic pathways. Consequently, experimental methodologies should be redesigned not merely to assess the antibiotic properties of compounds or metabolites, but to investigate their involvement in extracellular Fenton reactions and self\u2010protection mechanisms, which are fundamental to understanding their natural biological roles.<\/jats:p>","DOI":"10.1002\/cbdv.202500314","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T04:25:02Z","timestamp":1744604702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Essence of Nature Can be the Simplest (2)\u2013Self\u2010Inhibition Boundary: Keeping Away From Extracellular Fenton Reactions"],"prefix":"10.1002","volume":"22","author":[{"given":"Gang","family":"Dai","sequence":"first","affiliation":[{"name":"School of Life Sciences, State Key Laboratory for Conservation and Utilization of Bio\u2010Resources &amp; Key Laboratory for Microbial Resources of the Ministry of Education Yunnan University  Kunming P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhangxin","family":"Zuo","sequence":"additional","affiliation":[{"name":"School of Life Sciences, State Key Laboratory for Conservation and Utilization of Bio\u2010Resources &amp; Key Laboratory for Microbial Resources of the Ministry of Education Yunnan University  Kunming P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjie","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, State Key Laboratory for Conservation and Utilization of Bio\u2010Resources &amp; Key Laboratory for Microbial Resources of the Ministry of Education Yunnan University  Kunming P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenghong","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany Chinese Academy of Sciences  Kunming P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8977-8956","authenticated-orcid":false,"given":"Xuemei","family":"Niu","sequence":"additional","affiliation":[{"name":"School of Life Sciences, State Key Laboratory for Conservation and Utilization of Bio\u2010Resources &amp; Key Laboratory for Microbial Resources of the Ministry of Education Yunnan University  Kunming P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2019.06.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4832-3129-7.50037-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.69756"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-57996-x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.67.6.2705-2711.2001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02312-15"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-7915.70002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202500313"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-021-00310-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41529-021-00192-3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00324-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2022.07.003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.68.1767.437"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/21501203.2024.2324993"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e13066"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28248139"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21391"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116175"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-00114-z"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1004"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-022-2265-6"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202500314","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202500314","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202500314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:55:05Z","timestamp":1773010505000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202500314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,28]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/cbdv.202500314"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202500314","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,28]]},"assertion":[{"value":"2025-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202500314"}}