{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:45:52Z","timestamp":1788792352437,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The genus\n                    <jats:italic>Satureja<\/jats:italic>\n                    (Lamiaceae) includes many aromatic species with known antimicrobial, antioxidant, anti\u2010inflammatory, and anticancer properties.\n                    <jats:italic>Satureja hasturkii<\/jats:italic>\n                    H.Duman &amp; Dirmenci is a newly described species from T\u00fcrkiye (2023), and its biological potential has not been explored yet. In this study, dichloromethane (DCM), ethyl acetate (EtOAc), and ethanol (EtOH) extracts were assessed for their enzyme inhibitory activity against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), elastase, collagenase, tyrosinase (TYR), and xanthine oxidase (XO), along with their antioxidant activities using DPPH, nitric oxide (NO), metal\u2010chelation, ferric\u2010reducing antioxidant power (FRAP), and cupric\u2010reducing antioxidant capacity (CUPRAC) assays. The extracts showed low to moderate inhibition levels at 2\u00a0mg\/mL (stock concentration). The EtOAc extract showed the most effective elastase (16.70 \u00b1 2.08%) and collagenase (13.96 \u00b1 3.70%) inhibition. XO inhibition was highest with EtOH (34.34 \u00b1 0.60%), followed by EtOAc extract (30.32 \u00b1 2.03%). DCM extract displayed the strongest metal\u2010chelating activity (72.38 \u00b1 1.86%). Essential oil composition analyzed by GC\u2010MS revealed docosane, \u03b3\u2010terpinene, and\n                    <jats:italic>p<\/jats:italic>\n                    \u2010cymene as major constituents. HPLC analysis of the extracts identified rosmarinic acid and luteolin\u20107\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010glucoside as abundant phenolics. These results highlight the species\u2019 potential as a natural source of bioactive agents for pharmaceutical and nutraceutical applications.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500328","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T07:52:17Z","timestamp":1747641137000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Enzyme Inhibitory and Antioxidant Potential with Phytochemical Analysis of\n                    <i>Satureja hasturkii<\/i>\n                    H.Duman &amp; Dirmenci: A New Record From T\u00fcrkiye"],"prefix":"10.1002","volume":"22","author":[{"given":"Tugsen","family":"Buyukyildirim","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Selcuk University Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahriye","family":"Ocal Ozdamar","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science Gazi University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokcen","family":"Baysal Furtana","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science Gazi University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasya Nazli","family":"Gok","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Gazi University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temel","family":"Ozek","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Anadolu University Eskisehir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7379-5436","authenticated-orcid":false,"given":"Ilkay Erdogan","family":"Orhan","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Lokman Hekim University Ankara T\u00fcrkiye"},{"name":"Principal Member of Turkish Academy of Sciences (T\u00dcBA) Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Sezer","family":"Senol Deniz","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Gazi University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayri","family":"Duman","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science Gazi University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_8_2_1","article-title":"Lamiaceae Essential Oils, Phytochemical Profile, Antioxidant, and Biological Activities","volume":"2021","author":"Ramos da Silva L. 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