{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:25:14Z","timestamp":1789730714130,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry & Biodiversity"],"abstract":"ABSTRACT<\/jats:title>A novel series of benzofuran\/indole\u2010chalcone linked 1,2,3\u2010triazole hybrids (4a\u2013k<\/jats:bold>, 8a\u2013h<\/jats:bold>) were synthesized to explore their potential as antifungal agents. Among the 19 derivatives, 4b<\/jats:bold>, 4c<\/jats:bold>, 4i<\/jats:bold>, 4j<\/jats:bold>, and 8a<\/jats:bold> showed inhibition against Candida glabrata<\/jats:italic> at 50\u00a0\u00b5g\/mL concentration that is comparable to the control drug fluconazole. Compounds 4b<\/jats:bold>, 4c<\/jats:bold>, and 4j<\/jats:bold> showed greater activity at low concentrations (25 and 12.5\u00a0\u00b5g\/mL). Among them, 4j<\/jats:bold> exhibited the highest potency, with 81.82% inhibition against C. glabrata<\/jats:italic> at 50\u00a0\u00b5g\/mL. Compound 4j<\/jats:bold> exhibited better safety profiles against human acute monocytic leukemia cells. In structural activity studies, chloro (Cl) at the 2,6th position of the phenyl ring of chalcone and p<\/jats:italic>\u2010CN substitution on the benzyl triazole moiety maximizes the potential. In addition, in silico ADME analysis supports the drug\u2010likeness profile and strengthens the data. So, compound 4j<\/jats:bold> can be used as an effective lead to develop a potent and safer antifungal drug candidate to combat Candida<\/jats:italic> infections.<\/jats:p>","DOI":"10.1002\/cbdv.202500345","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T16:11:21Z","timestamp":1743178281000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Exploration of Benzofuran\/Indole\u2010Chalcone Conjugated 1,2,3\u2010Triazole Hybrids as Candida glabrata<\/i> Agents: Design, Synthesis, Biological Evaluation, Molecular Docking, and In Silico ADMET Analysis"],"prefix":"10.1002","author":[{"given":"Anuradha","family":"Singampalli","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rani","family":"Bandela","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pardeep","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bulti","family":"Bakchi","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarvan","family":"Maddipatla","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sri Mounika","family":"Bellapukonda","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6671-2022","authenticated-orcid":false,"given":"Srinivas","family":"Nanduri","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Life Sciences University of Hyderabad Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnaveni","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Life Sciences University of Hyderabad Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9813-8694","authenticated-orcid":false,"given":"Yaddanapudi Venkata","family":"Madhavi","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2018.26","article-title":"Invasive Candidiasis","volume":"4","author":"Pappas P. 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