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Using the MTT assay, we evaluated their antiproliferative effects against three human cancer cell lines: cervical cancer (HeLa), hepatocellular carcinoma (Huh\u20107), and triple\u2010negative breast cancer (MDA\u2010MB\u2010231). Most compounds demonstrated superior activity to matrine, with\n                    <jats:bold>W12<\/jats:bold>\n                    showing the strongest effects (IC\n                    <jats:sub>50<\/jats:sub>\n                    values: 4.8 \u00b1 0.33 \u00b5M for Huh\u20107, 8.03 \u00b1 1.28 \u00b5M for MDA\u2010MB\u2010231, and 10.11 \u00b1 0.39 \u00b5M for HeLa).\n                    <jats:bold>W12<\/jats:bold>\n                    induced concentration\u2010dependent morphological changes, G1 phase cell cycle arrest, apoptosis, and inhibited colony formation and migration. Molecular docking revealed that\n                    <jats:bold>W12<\/jats:bold>\n                    forms hydrogen bonds and other interactions with TRK\u2010related protein 5KVT. These findings suggest that\n                    <jats:bold>W12<\/jats:bold>\n                    is a promising anticancer drug precursor.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500358","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T13:49:51Z","timestamp":1751032191000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Design, Synthesis, In Vitro Evaluation of Antitumor Activity, and Molecular Docking Studies of D\u2010ring\u2010opened Indazole\u2010Matrine Derivatives as Potential Anticancer Agents"],"prefix":"10.1002","volume":"22","author":[{"given":"Hanqing","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Medicine Guangxi University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siying","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Medicine Guangxi University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal A. 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