{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T19:50:18Z","timestamp":1776714618791,"version":"3.51.2"},"reference-count":61,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In order to contribute to the fight against the antibiotic resistance crisis, we used a dual\u2010activity prospection strategy for natural product mixtures with antibiotic resistance modulating and antibacterial activities in the essential oils (EOs) of <jats:italic>Artemisia ludoviciana<\/jats:italic>, <jats:italic>Lippia graveolens<\/jats:italic>, and <jats:italic>Cosmos bipinnatus<\/jats:italic> against multidrug\u2010resistant strains of <jats:italic>Pseudomonas aeruginosa<\/jats:italic> HIM\u2010MR01, <jats:italic>Staphylococcus aureus<\/jats:italic> HIM\u2010MR02, <jats:italic>Enterococcus faecalis<\/jats:italic> HIM\u2010MR05, and <jats:italic>Salmonella typhi<\/jats:italic> HIM\u2010MR06. The three EOs exerted antibacterial activity on the bacterial strains with minimum inhibitory concentrations (MICs) ranging from 0.1735 to 65.6263\u00a0\u00b5g\/mL. When combined with antibiotics, the <jats:italic>L. graveolens<\/jats:italic> EO showed the highest resistance modulation for vancomycin (VA), nalidixic acid (NA), and chloramphenicol against <jats:italic>S. aureus<\/jats:italic> (MIC: 0.0347\u00a0\u00b5g\/mL), <jats:italic>E. faecalis<\/jats:italic> (MIC: 0.0832\u00a0\u00b5g\/mL), and <jats:italic>P. aeruginosa<\/jats:italic> (MIC: 0.0694\u00a0\u00b5g\/mL). For the <jats:italic>A. ludoviciana<\/jats:italic> EO, resistance modulation was based on <jats:italic>S. aureus<\/jats:italic>\u2010VA (MIC: 0.6525\u00a0\u00b5g\/mL) and <jats:italic>E. faecalis<\/jats:italic>\u2010NA (MIC: 0.3262\u00a0\u00b5g\/mL). Thereby, <jats:italic>C. bipinnatus<\/jats:italic> EO did not show significant antibiotic resistance modulating activity. In conclusion, <jats:italic>L. graveolens<\/jats:italic> and <jats:italic>A. ludoviciana<\/jats:italic> EOs showed antibacterial activity and the greatest potential in inhibiting bacterial resistance to antibiotics. The dual activity of these EOs makes them a promising adjuvant\u00a0in the treatment of diseases caused by multidrug\u2010resistant pathogenic bacteria.<\/jats:p>","DOI":"10.1002\/cbdv.202500405","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T19:34:36Z","timestamp":1744313676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antibacterial Essential Oils as Adjuvants to Inhibit Antibiotic Resistance in Multidrug\u2010resistant Bacteria"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7744-5129","authenticated-orcid":false,"given":"Rafael","family":"Torres\u2010Mart\u00ednez","sequence":"first","affiliation":[{"name":"Laboratorio de Ecolog\u00eda Qu\u00edmica y Agroecolog\u00eda Instituto de Investigaciones en Ecosistemas y Sustentabilidad, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Campus Morelia  Morelia Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8989-1836","authenticated-orcid":false,"given":"Yolanda Magdalena","family":"Garc\u00eda\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Laboratorio de Ecolog\u00eda Qu\u00edmica y Agroecolog\u00eda Instituto de Investigaciones en Ecosistemas y Sustentabilidad, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Campus Morelia  Morelia Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8168-4488","authenticated-orcid":false,"given":"Mar\u00eda Guadalupe","family":"Ram\u00edrez\u2010Ortiz","sequence":"additional","affiliation":[{"name":"Laboratorio de Ecolog\u00eda Qu\u00edmica y Agroecolog\u00eda Instituto de Investigaciones en Ecosistemas y Sustentabilidad, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Campus Morelia  Morelia Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5041-6264","authenticated-orcid":false,"given":"Tzasn\u00e1","family":"Hern\u00e1ndez\u2010Delgado","sequence":"additional","affiliation":[{"name":"Laboratorio de Fitoqu\u00edmica, Unidad de Biotecnolog\u00eda y Prototipos Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico  Tlalnepantla Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1394-6300","authenticated-orcid":false,"given":"Guillermo","family":"Delgado","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Exterior, Ciudad Universitaria  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"Espinosa\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratorio de Ecolog\u00eda Qu\u00edmica y Agroecolog\u00eda Instituto de Investigaciones en Ecosistemas y Sustentabilidad, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Campus Morelia  Morelia Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1004264"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2022.03.014"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0001305"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.onehlt.2017.11.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01867-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2411919121","article-title":"Global Trends in Antibiotic Consumption During 2016\u20132023 and Future Projections through 2030","volume":"121","author":"Klein E. 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