{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:56:21Z","timestamp":1785430581130,"version":"3.56.0"},"reference-count":61,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Syngonium (S.) podophyllum<\/jats:italic>\n                    L. is recognized for its diverse applications. This study evaluated the in vivo anti\u2010inflammatory and neuropharmacological properties of its methanolic flower extract (\n                    <jats:italic>S. podophyllum<\/jats:italic>\n                    flower methanolic extract [SPF\u2010ME]) using Swiss albino mice and its in vitro antioxidant capabilities. The anti\u2010inflammatory activity was assessed through the xylene\u2010induced ear edema method, whereas antioxidant properties were evaluated using 2,2\u2010Diphenyl\u20101\u2010picrylhydrazyl and 2,2'\u2010Azino\u2010bis(3\u2010ethylbenzothiazoline\u20106\u2010sulfonic acid) (ABTS) radical scavenging assays. Analgesic efficacy was tested with the acetic acid\u2010induced writhing and hot plate methods. Antidepressant effects were examined using the forced swimming test (FST) and the tail suspension test (TST), and anxiolytic activity was measured through the elevated plus maze (EPM) and hole board tests. Gas chromatography\u2013mass spectrometry (GC\u2013MS) was utilized to identify bioactive compounds, alongside in silico investigations using online tools for pass prediction, ADME\/T, and molecular docking. Results showed that SPF\u2010ME exhibited significant antioxidant activity, reduced edema (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05), and provided a notable analgesic effect (200\u00a0mg\/kg,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). It also demonstrated anxiolytic effects and reduced immobility time in both FST and TST (400\u00a0mg\/kg,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). Molecular docking analysis showed that the compounds in the extract exhibited binding affinities between \u22121.2 and \u221210.5\u00a0kcal\/mol for various human target receptors, including human cytochrome P450 CYP2C9, human cyclooxygenase\u20102 (COX\u20102), COX\u20102 inhibitors, human monoamine oxidase, and the human serotonin transporter, suggesting potential pharmacological activity. Overall, SPF\u2010ME is a promising natural source of antioxidants, anti\u2010inflammatory, and neuropharmacological agents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500425","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T05:53:51Z","timestamp":1744264431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Antioxidant,\u00a0Anti\u2010Inflammatory,\u00a0and\u00a0Neuropharmacological Potential of\n                    <i>Syngonium podophyllum<\/i>\n                    Flower Methanolic Extract: Insights From In Vivo, In Vitro, In Silico, and GC\u2013MS\/MS Analysis"],"prefix":"10.1002","volume":"22","author":[{"given":"Sakhaoyat","family":"Hossain","sequence":"first","affiliation":[{"name":"Department of Chemistry Chittagong University of Engineering and Technology Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7328-3633","authenticated-orcid":false,"given":"Sayed Al Hossain","family":"Rabbi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Government City College National University Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1926-6407","authenticated-orcid":false,"given":"Md. Jahirul Islam","family":"Mamun","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4267-2692","authenticated-orcid":false,"given":"M Abdullah Al","family":"Masum","sequence":"additional","affiliation":[{"name":"Department of Applied Food Science and Nutrition, Faculty of Food Science and Technology Chattogram Veterinary and Animal Sciences University Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5176-5891","authenticated-orcid":false,"given":"Khurshida Jahan","family":"Suma","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9514-1601","authenticated-orcid":false,"given":"Md. Hossain","family":"Rasel","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2354-1806","authenticated-orcid":false,"given":"Md. Amzad","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Science and Technology Chittagong Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4169-899X","authenticated-orcid":false,"given":"Mahathir","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Department of Chemistry Chittagong University of Engineering and Technology Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9269-5353","authenticated-orcid":false,"given":"Delower","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Medicine and Public Health, Faculty of Veterinary Medicine and Animal Science Sher\u2010e\u2010Bangla Agricultural University Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-102081-4.00002-2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imr.2024.101070"},{"key":"e_1_2_10_4_1","unstructured":"World Health Organization \u201cWHO Global Centre for Traditional edicine \u201dWorld Health Organization. [Cited 2022 Oct 08]88(2023):25. (World Health Organization) https:\/\/www.who.int\/initiatives\/who\u2010globalcentre\u2010for\u2010traditional\u2010medicine#:~:text."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113413"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4BM01221F"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394598-3.00003-4"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-006-0361-6"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2021.07.004"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12186"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/s2175-97902025e24066"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2003.5.3\/pmartin"},{"key":"e_1_2_10_13_1","first-page":"610","article-title":"Depressive Disorders","author":"Klein D. N.","year":"2017","journal-title":"Child and Adolescent Psychopathology"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27186021"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900009901"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/13651501.2012.667114"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.2047"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2021.101062"},{"key":"e_1_2_10_19_1","first-page":"3051","article-title":"A Review on Herbal Plants Showing Antidepressant Activity","volume":"2","author":"Jawaid T.","year":"2011","journal-title":"International Journal of Pharmaceutical Sciences"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2307\/2398892"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cropro.2024.106978"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40009-014-0318-4"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2306\/scienceasia1513-1874.2019.45.109"},{"key":"e_1_2_10_24_1","first-page":"5821","article-title":"Anti\u2010Inflammatory, Analgesic and Anti\u2010Oxidant Effects of Shirakiopsis indica (Willd). Fruit Extract: A Mangrove Species in the Field of Inflammation Research","author":"Jiko P. A.","year":"2024","journal-title":"Journal of Inflammation Research"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43094-021-00313-4"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr10051016"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2789482"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.13005\/bpj\/1229"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7384735"},{"key":"e_1_2_10_30_1","first-page":"85","article-title":"Anti\u2010inflammatory Effect of 3\u2010acetylaconitine","volume":"5","author":"Tang X. C.","year":"1984","journal-title":"Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica"},{"key":"e_1_2_10_31_1","first-page":"329","article-title":"Anti\u2010inflammatory and Antinociceptive Activities of Lippia nodiflora Linn","volume":"59","author":"Ahmed F.","year":"2004","journal-title":"Die Pharmazie\u2010An International Journal of Pharmaceutical Sciences"},{"key":"e_1_2_10_32_1","first-page":"111","article-title":"Studies on Analgesic and Anti\u2010inflammatory Activities of Cissampelos mucronata Linn. in Laboratory Animals","volume":"2","author":"Yaro A. H.","year":"2008","journal-title":"International Journal of Pure and Applied Researches"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)05180-8"},{"key":"e_1_2_10_34_1","first-page":"133","article-title":"Evaluation of the Neuroprotective Effects of Curcumin (turmeric) Against Scopolamine Induced Cognitive Impairment in Mice","volume":"6","author":"Sunanda B. P.","year":"2014","journal-title":"International Journal of Pharmaceutical and Phytopharmacological Research"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(95)00300-H"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00421184"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2006.07.007"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.03.008"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24101857"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.22159\/ijpps.2024v16i4.50478"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00104"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42717"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/384644a0"},{"key":"e_1_2_10_44_1","first-page":"186","article-title":"Structure Based Virtual Screening for DNA Methyl Transferase\u20101 Inhibitors","volume":"14","author":"Saddala M. S.","year":"2013","journal-title":"Online Journal of Bioinformatics"},{"key":"e_1_2_10_45_1","first-page":"112","article-title":"Antioxidant, Analgesic and Anti\u2010inflammatory Activities of the Methanolic Extract of Piper betle Leaves","volume":"3","author":"Alam B.","year":"2013","journal-title":"Avicenna Journal of Phytomedicine"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.12928\/pharmaciana.v10i3.16643"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.4504"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27041326"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02977613"},{"key":"e_1_2_10_50_1","volume-title":"StatPearls [Internet]","author":"Cascella M.","year":"2025"},{"key":"e_1_2_10_51_1","first-page":"698","article-title":"Analgesic Activity of the Aqueous Seed Extract of Hunteria umbellata (K. Schum.) Hallier f. in rodents","volume":"49","author":"Adeyemi O. O.","year":"2011","journal-title":"Indian Journal of Experimental Biology"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1983.tb10504.x"},{"key":"e_1_2_10_53_1","first-page":"344","article-title":"Antinociceptive and Sedative Effects of the Bark of Cerbera odollam Gaertn","volume":"6","author":"Ahmed F.","year":"2006","journal-title":"Advances in Traditional Medicine"},{"key":"e_1_2_10_54_1","first-page":"42","article-title":"In Vivo Analgesic Activity of Ethanolic Extracts of Two Medicinal Plants\u2010 Scoparia dulcis L. and Ficus racemosa Linn","volume":"2","author":"Zulfiker A. H. M.","year":"2010","journal-title":"Biology and Medicine"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(80)90377-5"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-007-0224-x"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28186573"},{"key":"e_1_2_10_58_1","first-page":"172","volume":"7","author":"Nahar U. J.","year":"2017","journal-title":"World Journal of Pharmaceutical Research"},{"key":"e_1_2_10_59_1","first-page":"327","volume":"229","author":"Porsolt R. D.","year":"1977","journal-title":"Archives Internationales De Pharmacodynamie Et De Therapie"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.123"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1515\/jcim-2018-0130"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13596-020-00429-7"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202500425","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202500425","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202500425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:54:17Z","timestamp":1773010457000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202500425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":61,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/cbdv.202500425"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202500425","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,29]]},"assertion":[{"value":"2025-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202500425"}}