{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:56:20Z","timestamp":1773028580525,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The current study describes the chemical profiles and biological activities of essential oils (EOs) from\n                    <jats:italic>Ziziphus leucodermis<\/jats:italic>\n                    stem and leaves for the first time. Higher quantity of \u03b2\u2010eudesmol (\n                    <jats:bold>1<\/jats:bold>\n                    ) was found in stem (43.4 \u00b1\u00a00.68%) compared to leave's oil, while leaves contained higher amounts of \u03b1\u2010bergamotene (\n                    <jats:bold>2,<\/jats:bold>\n                    13.5 \u00b1\u00a00.65%) and \u03b2\u2010eudesmene (\n                    <jats:bold>3<\/jats:bold>\n                    , 7.4 \u00b1\u00a00.51%) compared to stem. Significant potential was shown by leave's oil having IC\n                    <jats:sub>50<\/jats:sub>\n                    of 133.5 \u00b1\u00a00.80\u00a0\u00b5g\/mL than stem's oil (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 210.4 \u00b1\u00a00.20\u00a0\u00b5g\/mL) against breast cancer (MDA\u2010MB\u2010231) cells. Similarly, higher inhibition was observed by leave's oil (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 1.61 \u00b1\u00a00.08\u00a0\u00b5g\/mL) than stem's oil (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 2.39 \u00b1\u00a00.10) against \u03b1\u2010glucosidase enzyme, while stem (95.36 \u00b1\u00a02.10) determined higher carbonic anhydrase II activity than leaves (116.54 \u00b1\u00a00.86) compared to standards. Furthermore, only stem oil had significant antimicrobial activity against gram positive bacteria (\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ) having MIC of 12.5 \u00b1\u00a00.2 and fungi (\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    and\n                    <jats:italic>Candida kruzei<\/jats:italic>\n                    ) with an equal concentration of 50.0 \u00b1\u00a00.4\u00a0mm. The compounds identified in the stem and leaves oils were docked with the active pocket of \u03b1\u2010glucosidase enzyme. In conclusion, these EOs might be a natural source for the treatment of breast cancer, antimicrobial, and diabetes\u2010related diseases.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500434","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T01:53:06Z","timestamp":1744768386000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phytochemical Profiling, Biological Activities, and Molecular Docking Studies of Essential Oils from\n                    <i>Ziziphus leucodermis<\/i>\n                    (Baker) O. Schwartz"],"prefix":"10.1002","volume":"22","author":[{"given":"Noura","family":"Al\u2010Shaqsi","sequence":"first","affiliation":[{"name":"Natural &amp; Medical Sciences Research Center University of Nizwa  Nizwa Oman"},{"name":"Department of Chemistry Faculty of Science Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faizullah","family":"Khan","sequence":"additional","affiliation":[{"name":"Natural &amp; Medical Sciences Research Center University of Nizwa  Nizwa Oman"},{"name":"Department of Pharmacy Abdul Wali Khan University  Mardan Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Habib","family":"Al\u2010Jahdhami","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences Oman College of Health Sciences  Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Ullah","sequence":"additional","affiliation":[{"name":"Natural &amp; Medical Sciences Research Center University of Nizwa  Nizwa Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajmal","family":"Khan","sequence":"additional","affiliation":[{"name":"Natural &amp; Medical Sciences Research Center University of Nizwa  Nizwa Oman"},{"name":"Department of Chemical and Biological Engineering College of Engineering Korea University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atta","family":"Ullah","sequence":"additional","affiliation":[{"name":"Natural &amp; Medical Sciences Research Center University of Nizwa  Nizwa Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharifah","family":"Mohamad","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siew\u2010Huah","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Al\u2010Harrasi","sequence":"additional","affiliation":[{"name":"Natural &amp; Medical Sciences Research Center University of Nizwa  Nizwa Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1563-225X","authenticated-orcid":false,"given":"Najeeb Ur","family":"Rehman","sequence":"additional","affiliation":[{"name":"Natural &amp; Medical Sciences Research Center University of Nizwa  Nizwa Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2010.0787"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines11040725"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11051111"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2018.1488159"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2006.07.008"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.55544\/jrasb.2.1.8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof9070756"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202300002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1np00021g"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12030662"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12100907"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8054"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10068-022-01145-5"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2013.12.014"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339910791658826"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118239"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.04.004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants13162195"},{"key":"e_1_2_10_20_1","first-page":"246","volume-title":"The Natrual Heritage of Musandam, Misitry of Heritage and Tourism","author":"Saif Al Hatmi O. 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