{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:11:12Z","timestamp":1790046672433,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In this present work, in vitro lipoxygenase (LOX) inhibitory activities of methanol extracts and different fractions of six <jats:italic>Achillea<\/jats:italic> species [<jats:italic>A. biebersteinii, A. millefolium, A. cappadocica, A. wilhelmsii, A. setacea<\/jats:italic>, and <jats:italic>A. nobilis<\/jats:italic> subsp. <jats:italic>neilreichii<\/jats:italic>] were evaluated. A microplate\u2010based spectrophotometric method was utilized for the LOX assay. The phenolic composition was analyzed using the liquid chromatography\u2010high resolution mass spectrometer (LC\u2010HRMS). As a result, the <jats:italic>A. biebersteinii<\/jats:italic> (Malatya locality) ethyl acetate fraction showed the highest lipoxygenase inhibitory activity (72.9% inhibition), followed by the <jats:italic>A. cappadocica<\/jats:italic> ethyl acetate fractions with 66.9% and 60.4% inhibition, respectively. The phytochemical LC\u2010HRMS analyses revealed that the active constituents of the studied fractions were vanillic acid, hyperoside, <jats:italic>p<\/jats:italic>\u2010coumaric acid, quercetin, and chrysoeriol. The findings showed the active bioassay\u2010directed fractions, as well compounds to the best of our knowledge for the first time, suggesting further future biological, pharmacological, and toxicological evaluations both in vitro and in vivo.<\/jats:p>","DOI":"10.1002\/cbdv.202500466","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T17:13:42Z","timestamp":1748452422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anti\u2010lipoxygenase Evaluation of Different <i>Achillea<\/i> sp. Extracts"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1524-3617","authenticated-orcid":false,"given":"Bilgen","family":"Suba\u015f\u0131","sequence":"first","affiliation":[{"name":"Ministry of National Defense, Pharmaceutical Factory Directorate  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1138-3145","authenticated-orcid":false,"given":"Tu\u011fba","family":"G\u00fcnbatan","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Gazi University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3670-0899","authenticated-orcid":false,"given":"\u0130lhan","family":"G\u00fcrb\u00fcz","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Gazi University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6022-1644","authenticated-orcid":false,"given":"Ebrar","family":"\u0130nal","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Bezmialem Vakif University  Istanbul T\u00fcrkiye"},{"name":"Bezmialem Center of Education, Practice, and Research in Phytotherapy Bezmialem Vakif University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3538-2769","authenticated-orcid":false,"given":"Murat","family":"Kartal","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Bezmialem Vakif University  Istanbul T\u00fcrkiye"},{"name":"Bezmialem Center of Education, Practice, and Research in Phytotherapy Bezmialem Vakif University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7594-5178","authenticated-orcid":false,"given":"Melike","family":"Sucu","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Baskent University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1411-7184","authenticated-orcid":false,"given":"Mehmet Sina","family":"\u0130\u00e7en","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy \u0130n\u00f6n\u00fc University  Malatya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1497-3017","authenticated-orcid":false,"given":"Fatih","family":"Demirci","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Anadolu University  Eskisehir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"173","article-title":"A Review on Phytochemistry and Medicinal Properties of the Genus Achillea","volume":"19","author":"Saeidnia S.","year":"2011","journal-title":"DARU Journal of Pharmaceutical Sciences"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3906\/bot-1905-13"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjps.galenos.2021.12574"},{"key":"e_1_2_9_5_1","unstructured":"A.Guner S.Aslan T.Ekim M.Vural andM. 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