{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:55:22Z","timestamp":1783612522917,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The coronavirus disease (COVID\u201019) endemic has urged an intensive search for effective treatments to fight the infections. The lack of effective medication against SARS\u2010CoV\u20102 infections has led to alternative treatment approaches, with medicinal plants as promising candidates in the ongoing development of anti\u2010SARS\u2010CoV\u20102 therapeutics. In this present study, apigenin\u20106\u2010C\u2010\u03b2\u2010glucoside\u20104\u2032\u2010O\u2010\u03b1\u2010apiofuranoside (AGA), a phytochemical compound found in\n                    <jats:italic>Christia vespertilionis<\/jats:italic>\n                    methanolic leaves extract (MeCV) was screened for anti\u2010SARS\u2010CoV\u20102 via in silico molecular docking approach on angiotensin\u2010converting enzyme 2 (ACE2) receptor. The methanol extract, fractions, and AGA were assessed for in vitro anti\u2010SARS\u2010CoV\u20102 assay. Molecular docking analysis showed that AGA (\u221271.7\u00a0kJ\/mol) demonstrated potential binding interactions with ACE2 residues comparable to MLN\u20104760 (\u221270.4\u00a0kJ\/mol), a potent and selective human ACE2 inhibitor. The in vitro result revealed that methanolic extract exhibited the highest antiviral effect compared to other tested samples. These findings suggest that methanol extract contains active antiviral compounds and could be the potential anti\u2010SARS\u2010CoV\u20102 agent.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500478","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T19:48:17Z","timestamp":1754682497000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Apigenin Isolated From\n                    <i>Christia vespertilionis<\/i>\n                    Leaves on Anti\u2010SARS\u2010CoV\u20102 Activity: In Silico and In Vitro Studies"],"prefix":"10.1002","volume":"22","author":[{"given":"Nur Ainina Hani","family":"Ghazali","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy and Health Sciences, Royal College of Medicine Perak Universiti Kuala Lumpur  Ipoh Perak 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