{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:15:51Z","timestamp":1783041351046,"version":"3.54.6"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Euphorbia prolifera<\/jats:italic>, classified under the genus <jats:italic>Euphorbia<\/jats:italic> within the Euphorbiaceae family,\u00a0is a perennial herbaceous plant. This plant exhibits a distinct biogeographical preference, with its natural populations predominantly located in the eastern and southeastern territories of the Asian continent. The roots and stems of <jats:italic>E. prolifera<\/jats:italic> have been investigated as a rich source of diterpenoids, and 12 lathyrane diterpenoids, including three previously undescribed ones, were isolated. Their structures were determined by analysing spectroscopic data (one\u2010 and two\u2010dimensional nuclear magnetic resonance), and high\u2010resolution electrospray ionization mass spectrometry, and by comparing them with previously published data. Meanwhile, all the compounds were evaluated for in vitro anti\u2010inflammatory bioactivities. The findings indicated that compound <jats:bold>8<\/jats:bold> exhibited superior inhibitory effects compared with the positive control drug (dexamethasone) on nitric oxide production in lipopolysaccharide\u2010induced RAW264.7 cells with a minimum inhibitory concentration value of 3.95 \u00b1 0.49 \u00b5M. Using target screening and molecular docking technology, it is hypothesized that compound <jats:bold>8<\/jats:bold> may play an anti\u2010inflammatory role by combining with human Filamin\u2010B.<\/jats:p>","DOI":"10.1002\/cbdv.202500495","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T13:23:32Z","timestamp":1743513812000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lathyrane Diterpenoids From the Roots and Stems of <i>Euphorbia prolifera<\/i> and Their Anti\u2010inflammatory Activity"],"prefix":"10.1002","author":[{"given":"Kexin","family":"Liu","sequence":"first","affiliation":[{"name":"Wuya College of Innovation, Key Laboratory of Structure\u2010Based Drug Design &amp; Discovery, Ministry of Education Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xu","sequence":"additional","affiliation":[{"name":"Wuya College of Innovation, Key Laboratory of Structure\u2010Based Drug Design &amp; Discovery, Ministry of Education Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Structural Pharmacology &amp; TCM Chemical Biology, Fujian Key Laboratory of Chinese Materia Medica, College of Pharmacy Fujian University of Traditional Chinese Medicine  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Wuya College of Innovation, Key Laboratory of Structure\u2010Based Drug Design &amp; Discovery, Ministry of Education Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Wuya College of Innovation, Key Laboratory of Structure\u2010Based Drug Design &amp; Discovery, Ministry of Education Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Li","sequence":"additional","affiliation":[{"name":"Wuya College of Innovation, Key Laboratory of Structure\u2010Based Drug Design &amp; Discovery, Ministry of Education Shenyang Pharmaceutical University  Shenyang China"},{"name":"Institute of Structural Pharmacology &amp; TCM Chemical Biology, Fujian Key Laboratory of Chinese Materia Medica, College of Pharmacy Fujian University of Traditional Chinese Medicine  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Chen","sequence":"additional","affiliation":[{"name":"Wuya College of Innovation, Key Laboratory of Structure\u2010Based Drug Design &amp; Discovery, Ministry of Education Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,26]]},"reference":[{"key":"e_1_2_8_2_1","volume":"11","author":"Editorial Committee of Flora of China","year":"2008","journal-title":"Chinese Academy of Sciences Flora of China"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-023-09900-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.04.052"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b02021"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2024.114548"},{"key":"e_1_2_8_7_1","first-page":"4553","article-title":"Antibacterial Activity of New Polyester Diterpenes From Euphorbia guyoniana","volume":"6","author":"El\u2010Bassuony A. 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