{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:28:57Z","timestamp":1790908137983,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Two previously undescribed sesquiterpenoids, including one germacrane sesquiterpenoid (\n                    <jats:bold>1<\/jats:bold>\n                    ) and one guaiane sesquiterpenoid (\n                    <jats:bold>2<\/jats:bold>\n                    ), were isolated and characterized from the branches and leaves of\n                    <jats:italic>Michelia alba<\/jats:italic>\n                    DC., along with 11 known sesquiterpenoids (\n                    <jats:bold>3<\/jats:bold>\n                    \u2013\n                    <jats:bold>13<\/jats:bold>\n                    ). The structures of the new compounds were elucidated using comprehensive high\u2010resolution electrospray ionization mass spectroscopy, infrared, ultraviolet, and nuclear magnetic resonance analyses, with the absolute configurations being determined through single\u2010crystal X\u2010ray diffraction analysis and electronic circular dichroism calculations. Furthermore, this study also presented the proton and carbon\u201013 nuclear magnetic resonance data for\n                    <jats:bold>3<\/jats:bold>\n                    for the first time. All isolated compounds were evaluated for their cytotoxic effects against HL\u201060, A549, HepG2, MDA\u2010MB\u2010231, and SW480 cancer cell lines using the 3\u2010(4,5\u2010dimethylthiazol\u20102\u2010yl)\u20105(3\u2010carboxymethoxyphenyl)\u20102\u2010(4\u2010sulfopheny)\u20102H\u2010tetrazolium bromide assay, as well as their ability to inhibit lipopolysaccharide\u2010induced nitric oxide (NO) production in RAW264.7 macrophages. Notably, compound\n                    <jats:bold>7<\/jats:bold>\n                    showed remarkable cytotoxic activity against HL\u201060, HepG2, MDA\u2010MB\u2010231, and SW480 cancer cell lines, with half\u2010maximal inhibitory concentration (IC\n                    <jats:sub>50<\/jats:sub>\n                    ) values of 3.44 \u00b1\u00a00.19, 8.13 \u00b1\u00a00.43, 3.69 \u00b1\u00a00.14, and 3.50 \u00b1\u00a00.21 \u00b5M, respectively. Additionally, compounds\n                    <jats:bold>4<\/jats:bold>\n                    ,\n                    <jats:bold>7<\/jats:bold>\n                    , and\n                    <jats:bold>13<\/jats:bold>\n                    demonstrated notable NO inhibitory activities, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 3.26 \u00b1\u00a00.04, 1.48 \u00b1\u00a00.07, and 8.54 \u00b1\u00a00.37 \u00b5M, respectively.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500499","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T16:20:14Z","timestamp":1744042814000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diverse Sesquiterpenoids From\n                    <i>Michelia alba<\/i>\n                    and Their Cytotoxic and Nitric Oxide Inhibitory Activities"],"prefix":"10.1002","volume":"22","author":[{"given":"Ting\u2010Yue","family":"Zheng","sequence":"first","affiliation":[{"name":"Key Laboratory of Ethnic Medicine Resource Chemistry Ministry of Education, Yunnan Minzu University Kunming P. R. China"},{"name":"School of Pharmaceutical Science &amp; Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical University Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin\u2010Fen","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science &amp; Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical University Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu\u2010Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ethnic Medicine Resource Chemistry Ministry of Education, Yunnan Minzu University Kunming P. R. China"},{"name":"School of Pharmaceutical Science &amp; Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical University Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen\u2010Quan","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ethnic Medicine Resource Chemistry Ministry of Education, Yunnan Minzu University Kunming P. R. China"},{"name":"School of Pharmaceutical Science &amp; Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical University Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu\u2010Ye","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ethnic Medicine Resource Chemistry Ministry of Education, Yunnan Minzu University Kunming P. R. China"},{"name":"School of Pharmaceutical Science &amp; Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical University Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Ling","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ethnic Medicine Resource Chemistry Ministry of Education, Yunnan Minzu University Kunming P. R. China"},{"name":"School of Pharmaceutical Science &amp; Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical University Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu\u2010Dong","family":"Song","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science &amp; Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical University Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Chao","family":"Tu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ethnic Medicine Resource Chemistry Ministry of Education, Yunnan Minzu University Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2526-1269","authenticated-orcid":false,"given":"Xing\u2010De","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ethnic Medicine Resource Chemistry Ministry of Education, Yunnan Minzu University Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Flora of China","author":"Editorial Committee of Flora of China","year":"1996"},{"key":"e_1_2_9_3_1","first-page":"2608","article-title":"Sesquiterpenes Constituents From Fruits of Michelia Yunnanensis","volume":"48","author":"Ding L. 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