{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T15:04:11Z","timestamp":1778771051667,"version":"3.51.4"},"reference-count":71,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This research emphasized the extraction and separation of polysaccharides derived from\n                    <jats:italic>Syzygium jambos<\/jats:italic>\n                    (L.) Alston (PSJAP\u20105), as well as analyses of their structural characteristics and immunomodulatory activities. This study initially employed response surface methodology to determine the extraction conditions of polysaccharides. The average molecular weight of PSJAP\u20105 was 58\u00a0102\u00a0Da, and its monosaccharide composition was galactose, arabinose, galacturonic acid, glucuronic acid, and rhamnose (39.84:29.13:21.97:6.02:4.17). In vitro studies showed that PSJAP\u20105 promoted the proliferation and phagocytosis of macrophages. Meanwhile, PSJAP\u20105 (25\u2013200\u00a0\u00b5g\/mL) promoted the release of NO and ROS, and increased the levels of IL\u20106, TNF\u2010\u03b1, and IL\u20101\u03b2. After pretreating macrophages with TLR4, NF\u2010\u03baB, and MAPK inhibitors, the immunoenhancing effects of PSJAP\u20105 on macrophages treated with the inhibitors were decreased. Similarly, PSJAP\u20105 promoted the phosphorylation of p38 in the MAPK signaling pathway and reduced the phosphorylation of I\u03baB\u03b1 in the NF\u2010\u03baB signaling pathway in RAW264.7 cells. PSJAP\u20105 might serve as a potential immunomodulator for the treatment of diseases characterized by impaired immune function.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500537","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T20:26:31Z","timestamp":1757363191000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ultrasonic extraction, Structural Characterization, and Immunoactivity of Polysaccharides From\n                    <i>Syzygium jambos<\/i>\n                    (L.) 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