{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:00:10Z","timestamp":1787792410137,"version":"build-2784847793"},"reference-count":53,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The biological activities and phytochemical composition of\n                    <jats:italic>Alchemilla daghestanica<\/jats:italic>\n                    and\n                    <jats:italic>Alchemilla minusculiflora<\/jats:italic>\n                    were investigated for the first time. Methanol extracts from the aerial and root parts of both species were assessed. The total phenolic content was highest in the root extracts.\n                    <jats:italic>A. daghestanica<\/jats:italic>\n                    root (Alda root) and\n                    <jats:italic>A. minusculiflora<\/jats:italic>\n                    root (Almin root) exhibited by 91.58% radical scavenging activity at 200\u00a0\u00b5g\/mL, comparable to gallic acid (91.98%). Alda root inhibited COX\u20101 by 85.79% and COX\u20102 by 91.89% at 200\u00a0\u00b5g\/mL, while Almin root inhibited COX\u20101 by 83.99% and COX\u20102 by 91.82%. Elastase inhibition was highest in Almin root (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a040.35\u00a0\u00b5g\/mL). No significant collagenase inhibition was found. Wound\u2010healing assays demonstrated that root extracts exhibited the most rapid closure at 250\u00a0\u00b5g\/mL after 24\u00a0h. Key bioactive compounds, identified by LC\u2013MS\/MS, were catechin and ellagic acid, which may contribute to the observed biological effects.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500539","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T20:09:52Z","timestamp":1757362192000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Biological and Phytochemical Investigations of\n                    <i>Alchemilla daghestanica<\/i>\n                    Juz. and\n                    <i>Alchemilla minusculiflora<\/i>\n                    Buser: A Focus on Anti\u2010Inflammatory and Skin\u2010Regenerative Properties"],"prefix":"10.1002","volume":"22","author":[{"given":"Mertcan","family":"Ortahisar","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Karadeniz Technical University  Trabzon T\u00fcrkiye"},{"name":"Department of Pharmacognosy Institute of Health Science, Karadeniz Technical University  Trabzon T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu\u011fba","family":"\u00c7\u0131\u011f\u015far","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science Karadeniz Technical University  Trabzon T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8553-9093","authenticated-orcid":false,"given":"G\u00f6k\u00e7e","family":"Seyhan","sequence":"additional","affiliation":[{"name":"Biochemistry Department Faculty of Pharmacy Karadeniz Technical University  Trabzon T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0711-951X","authenticated-orcid":false,"given":"Didem","family":"Akkaya","sequence":"additional","affiliation":[{"name":"Biochemistry Department Faculty of Pharmacy Karadeniz Technical University  Trabzon T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9558-7048","authenticated-orcid":false,"given":"Selcen \u00c7elik","family":"Uzuner","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science Karadeniz Technical University  Trabzon T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7441-8771","authenticated-orcid":false,"given":"Burak","family":"Barut","sequence":"additional","affiliation":[{"name":"Biochemistry Department Faculty of Pharmacy Karadeniz Technical University  Trabzon T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7617-1701","authenticated-orcid":false,"given":"Nurdan","family":"Yazici","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Karadeniz Technical University  Trabzon 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