{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:14:14Z","timestamp":1792440854642,"version":"4.5.0"},"reference-count":72,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In the search of some new therapeutic agents against microbial infections, a series of pentacoordinated diorganotin(IV) complexes [R\n                    <jats:sub>2<\/jats:sub>\n                    SnL\n                    <jats:sup>1\u20132<\/jats:sup>\n                    ] were prepared by reacting 2\u2010(4\u2010chloro\u20102\u2010methylphenoxy)acetohydrazide and 3\u2010ethoxy\/5\u2010nitrosalicylaldehyde with R\n                    <jats:sub>2<\/jats:sub>\n                    SnCl\n                    <jats:sub>2<\/jats:sub>\n                    (R\u00a0=\u00a0Me,\n                    <jats:italic>n<\/jats:italic>\n                    \u2010Bu, Et, Ph). Various spectral techniques, including NMR (\n                    <jats:sup>1<\/jats:sup>\n                    H,\n                    <jats:sup>13<\/jats:sup>\n                    C,\n                    <jats:sup>119<\/jats:sup>\n                    Sn), FT\u2010IR, and HRMS, confirmed their pentacoordinated geometry of complexes, further validated by single\u2010crystal x\u2010ray diffraction (SC\u2010XRD) analysis of complex\n                    <jats:bold>3<\/jats:bold>\n                    [Me\n                    <jats:sub>2<\/jats:sub>\n                    SnL\n                    <jats:sup>1<\/jats:sup>\n                    ] that displays monoclinic crystal system with a deformed square\u2010pyramidal geometry around the tin metal center, with two methyl groups, N\n                    <jats:sub>azomethine<\/jats:sub>\n                    , O\n                    <jats:sub>phenolic<\/jats:sub>\n                    , and O\n                    <jats:sub>enolic<\/jats:sub>\n                    atoms. Furthermore, the antimicrobial study shows that all synthesized compounds (\n                    <jats:bold>1\u201310<\/jats:bold>\n                    ) exhibit significant activity against microbial infections. Among them, complexes\n                    <jats:bold>6<\/jats:bold>\n                    and\n                    <jats:bold>10<\/jats:bold>\n                    demonstrated the highest efficacy. Findings confirmed that the biological activity of complexes surpasses that of ligands (\n                    <jats:bold>1, 2<\/jats:bold>\n                    ) itself, with complex\n                    <jats:bold>6<\/jats:bold>\n                    [Ph\n                    <jats:sub>2<\/jats:sub>\n                    SnL\n                    <jats:sup>1<\/jats:sup>\n                    ] demonstrating highest efficiency in controlling microbial infections with minimum inhibitory concentration (MIC) values of 0.0049\u00a0\u00b5mol\/mL against\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    and\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    and comparable to standard drugs such as ciprofloxacin and fluconazole. To validate the enhanced antimalarial potential of the ligand\n                    <jats:bold>1<\/jats:bold>\n                    and its complexes (\n                    <jats:bold>3\u20136<\/jats:bold>\n                    ), density functional theory (DFT) calculations were performed on all synthesized compounds.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500544","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T11:15:43Z","timestamp":1745320543000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Integrated Experimental and Theoretical Studies of Organotin(IV)\u2010Hydrazone Complexes: Synthesis, Structural Elucidation, Computational Insights, and Antimicrobial Activity"],"prefix":"10.1002","volume":"22","author":[{"given":"Pinki","family":"Barwa","sequence":"first","affiliation":[{"name":"Department of Chemistry Guru Jambheshwar University of Science &amp; Technology  Hisar Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonika","family":"Asija","sequence":"additional","affiliation":[{"name":"Department of Chemistry Guru Jambheshwar University of Science &amp; Technology  Hisar Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kashmiri","family":"Lal","sequence":"additional","affiliation":[{"name":"Department of Chemistry Guru Jambheshwar University of Science &amp; Technology  Hisar Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh","family":"Deswal","sequence":"additional","affiliation":[{"name":"Department of Chemistry Central University of Haryana  Mahendergarh Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagat Singh","family":"Kirar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Govt. 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College  Guna Madhya Pradesh India"},{"name":"Department of Chemistry Krantivir Tatya Tope Vishwavidyalaya  Guna Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikha","family":"Poonia","sequence":"additional","affiliation":[{"name":"Department of Chemistry Guru Jambheshwar University of Science &amp; Technology  Hisar Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju","family":"Ragshaniya","sequence":"additional","affiliation":[{"name":"Department of Chemistry Guru Jambheshwar University of Science &amp; Technology  Hisar Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-024-00636-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b11203"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201503437"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2013.09.008"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00313C"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.6b01574"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00143386"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2017.05.005"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11131946"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11164-023-05179-0"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2019.103580"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.33263\/BRIAC106.69366963"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202402619"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.132305"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113602"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2005.12.025"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-8545(01)00399-X"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3329\/bjp.v10i3.23381"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/10426507.2012.686546"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/00958972.2016.1217408"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.7849"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.140273"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.7632"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10812-021-01189-1"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.7481"},{"key":"e_1_2_9_27_1","first-page":"4142","article-title":"Nano\u2010Synthesis Approach, Elaborated Spectral, Biological Activity and In Silico Assessment of Novel Nano\u2010Metal Complexes Based on Sulfamerazine Azo Dye","volume":"30","author":"Khedr A. 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