{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:06:53Z","timestamp":1791022013459,"version":"4.1.0"},"reference-count":93,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Ipomoea purpurea<\/jats:italic>\n                    , a traditional medicinal plant native to Mexico and Central America, was evaluated for its neuropharmacological effects. The methanol extract of\n                    <jats:italic>I. purpurea<\/jats:italic>\n                    leaves (IPML) was analyzed through in vivo and in silico approaches. The extract's secondary metabolites were identified through qualitative and gas chromatography\u2013mass spectrometry (GC\u2013MS) analysis. Anxiolytic effects were assessed using the elevated plus maze (EPM) and hole\u2010board test (HBT), whereas sedative activity was evaluated through the open\u2010field test (OFT) and hole cross test (HCT). Antidepressant properties were analyzed via the tail suspension test (TST) and forced swimming test (FST), and muscle relaxant activity was tested using the rota\u2010rod test. IPML at 200 and 400\u00a0mg\/kg showed significant anxiolytic (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001), sedative (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.0001), antidepressant (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001), and muscle relaxant (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.0001) effects. GC\u2013MS analysis identified 19 bioactive compounds, and in silico molecular docking and absorption, distribution, metabolism, excretion, and toxicity (ADME\/T) analysis revealed strong binding affinities, favorable pharmacokinetics, and a safe toxicological profile. Findings suggest that IPML possesses significant neuropharmacological properties, supporting its role as a natural therapeutic agent. However, further research is needed to address key concerns, such as small sample sizes, limited replication, and the necessity for extensive dose\u2013response studies across diverse animal models.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500560","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T22:20:30Z","timestamp":1745360430000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Investigating the Secondary Metabolite Profile and Neuropharmacological Activities of\n                    <i>Ipomoea purpurea<\/i>\n                    : A Multi\u2010Method Approach Using GC\u2013MS, In Vivo, and In Silico Techniques"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7632-5157","authenticated-orcid":false,"given":"Mohammad Rashedul","family":"Islam","sequence":"first","affiliation":[{"name":"Department of Pharmacy Faculty of Biological Sciences University of Chittagong Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3473-5244","authenticated-orcid":false,"given":"Md. Tanvir","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Biological Sciences University of Chittagong Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7887-1090","authenticated-orcid":false,"given":"Md. Mustafiz","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Biological Sciences University of Chittagong Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8195-7378","authenticated-orcid":false,"given":"Bibi Humayra","family":"Khanam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Biological Sciences University of Chittagong Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1945-6598","authenticated-orcid":false,"given":"Md. Liakot","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Biological Sciences University of Chittagong Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9400-8733","authenticated-orcid":false,"given":"Md. 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