{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:06:00Z","timestamp":1773014760775,"version":"3.50.1"},"reference-count":70,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Dicranopteris linearis<\/jats:italic>\n                    and\n                    <jats:italic>Paramignya trimera<\/jats:italic>\n                    , widely utilized plants in traditional Vietnamese medicine, lack comprehensive chemical and biological data pertaining to their composition. The crude extracts of these biosources showed remarkable alpha\u2010glucosidase and nitric oxide (NO) inhibition. Bioguided isolation based on alpha\u2010glucosidase inhibition and anti\u2010inflammatory activity was applied to\n                    <jats:italic>P. trimera<\/jats:italic>\n                    and\n                    <jats:italic>D. linearis<\/jats:italic>\n                    , providing 14 metabolites. Upon evaluating the alpha\u2010glucosidase activity of compounds\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>14<\/jats:bold>\n                    , it was observed that all tested compounds exhibited significant activity, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging from 22.5 to 157.7\u00a0\u00b5M. Notably, compound\n                    <jats:bold>14<\/jats:bold>\n                    was identified as a new compound. Compounds\n                    <jats:bold>6<\/jats:bold>\n                    \u2013\n                    <jats:bold>8<\/jats:bold>\n                    exhibited potent NO inhibitory effect in LPS\u2010induced RAW264.7 macrophage cells, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging from 26.65 to 28.79\u00a0\u00b5g\/mL.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500588","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T03:25:26Z","timestamp":1744601126000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Alpha\u2010Glucosidase and Nitric Oxide Inhibitors From\n                    <i>Paramignya trimera<\/i>\n                    Leaves and\n                    <i>Dicranopteris linearis<\/i>\n                    Spores: In Silico and In Vitro Aspects"],"prefix":"10.1002","volume":"22","author":[{"given":"Huong Thuy","family":"Le","sequence":"first","affiliation":[{"name":"Research Group in Pharmaceutical and Biomedical Sciences, Faculty of Pharmacy Ton Duc Thang University Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuan\u2010Dat","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Chemistry Ho Chi Minh City University of Education Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anh\u2010Ky","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Chemistry Ho Chi Minh City University of Education Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi\u2010Phuong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"NTT Hi\u2010Tech Institute Nguyen Tat Thanh University Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi\u2010My\u2010Duyen","family":"Ngo","sequence":"additional","affiliation":[{"name":"Research Group in Pharmaceutical and Biomedical Sciences, Faculty of Pharmacy Ton Duc Thang University Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi\u2010Hoai\u2010Thu","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Faculty of Fundamental Sciences University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan\u2010Hao","family":"Bui","sequence":"additional","affiliation":[{"name":"Department of Chemistry Ho Chi Minh City University of Education Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jirapast","family":"Sichaem","sequence":"additional","affiliation":[{"name":"Research Unit in Natural Products Chemistry and Bioactivities, Faculty of Science and Technology Thammasat University Lampang Campus Lampang Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9891-4326","authenticated-orcid":false,"given":"Thuc\u2010Huy","family":"Duong","sequence":"additional","affiliation":[{"name":"Department of Chemistry Ho Chi Minh City University of Education Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngoc\u2010Hong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"CirTech Institute HUTECH University Ho Chi Minh City 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