{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T03:17:03Z","timestamp":1789269423077,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Syzygium jambos<\/jats:italic>\n                    (L.) Alston fruits, a traditional medicinal species in the Myrtaceae family, are rich in polyphenolic compounds. This study optimized polyphenol extraction from\n                    <jats:italic>S. jambos<\/jats:italic>\n                    fruits using ultrasonic\u2010assisted extraction combined with response surface methodology, achieving a total polyphenol content (TPC) of 31.24\u00a0mg\/g. To further enrich polyphenols, crude extracts (CEs) were fractionated using solvents of increasing polarity (petroleum ether, dichloromethane, and ethyl acetate). Results showed that the ethyl acetate phase (EAP) had the highest TPC (96.25\u00a0mg\/g, threefold higher TPC than CE) and strongest antioxidant activity. In addition, polyphenol extracts demonstrated excellent biocompatibility, significant tyrosinase inhibition, and antibacterial activity against\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    and\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    , with inhibition zones of 16.2\u00a0\u00b1\u00a00.5 and 14.3\u00a0\u00b1\u00a00.6\u00a0mm at 100\u00a0mg\/mL. Finally, 41 polyphenolic compounds were identified by liquid chromatography\u2013mass spectrometry (LC\u2013MS) in EAP, including flavonoids (quercetin, isorhamnetin, and rutin), phenolic acids (caffeic acid and ferulic acid), and tannins (corilagin). These results demonstrate the potential of\n                    <jats:italic>S. jambos<\/jats:italic>\n                    polyphenols as natural additives for antioxidant, skin\u2010whitening, and antimicrobial applications.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500594","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T17:39:52Z","timestamp":1753119592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["RSM\u2010Optimized Extraction and Evaluation of Bioactivities of Polyphenols From\n                    <i>Syzygium jambos<\/i>\n                    (L.) Alston Fruits"],"prefix":"10.1002","volume":"22","author":[{"given":"Yang","family":"Li","sequence":"first","affiliation":[{"name":"Laboratory of Advanced Biomedical Materials (NFU\u2010UGent), Jiangsu Co\u2010Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Analysis and Testing Center Xinjiang Academy of Agriculture and Reclamation Science  Shihezi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anquan","family":"Yang","sequence":"additional","affiliation":[{"name":"OSM Biological Company Limited  Deqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xie","sequence":"additional","affiliation":[{"name":"OSM Biological Company Limited  Deqing 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