{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T04:26:48Z","timestamp":1782016008482,"version":"3.54.5"},"reference-count":73,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Although medicinal plants have the potential to be used therapeutically, little is known about the bioactive components and environmental stress reactions of the Algerian Saharan plant\n                    <jats:italic>Pituranthos scoparius<\/jats:italic>\n                    . The biological activity, phytochemical composition, adaptability, and molecular docking of the plant were evaluated in this work, along with dynamics simulations (in silico) that analyze how plant phytochemicals inhibit\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    LasR. In addition, osmolytes linked to edaphic factors and stresses were investigated in soil samples from Adrar. This latter was characterized by moderate limestone, low salinity, high potassium, and low phosphorus. Glycine betaine, proline, soluble carbohydrates, chlorophyll, and carotenoids were all present in stressed plants. GC\u2010MS analysis revealed 40 major essential oil components, including \u03b2\u2010phellandrene and exo\u20102\u2010hydroxyanisole, while LC\u2010MS detected \u03b2\u2010carotene, riboflavin, and ascorbic acid. The ethanolic extract (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a0164.86\u00a0\u00b1\u00a029.92\u00a0\u00b5g\/mL) and essential oil (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a0188.46\u00a0\u00b1\u00a05.49\u00a0\u00b5g\/mL) exhibited DPPH radical scavenging activity. Furthermore, the anti\u2010inflammatory tests showed inhibition of albumin denaturation by the ethanolic extract (84.46\u00a0\u00b1\u00a00.008%) and essential oil (62.25\u00a0\u00b1\u00a00.015%) at 10\u00a0mg\/mL. The ethanolic extract (100\u00a0mg\/mL) also exhibited antibacterial activity, inhibiting\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    and\n                    <jats:italic>Enterococcus faecalis<\/jats:italic>\n                    (34\u00a0mm zones). On the other hand, the in silico analysis revealed that quercetin, methylbicyclo(4.4.0)decane (\n                    <jats:italic>cis<\/jats:italic>\n                    ), and cianidanol effectively bound to and suppressed LasR. This study investigated the adaptability, phytochemical profile, biological activities, and microbial interactions of\n                    <jats:italic>P. scoparius<\/jats:italic>\n                    using in silico methods. The identification of key bioactive compounds and their antioxidant, anti\u2010inflammatory, and antibacterial properties, including LasR inhibition, provides valuable insights for drug development.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500643","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T07:56:02Z","timestamp":1744617362000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Revealing the Therapeutic Potential\n                    <i>of Pituranthos scoparius<\/i>\n                    : Phytochemical Composition, Biological Activities, and Abiotic Stress Resilience Through In Vitro and In Silico Analyses From the Algerian Sahara"],"prefix":"10.1002","volume":"22","author":[{"given":"Bariza","family":"Frih","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Nature and Life Sciences University of El Oued  El Oued Algeria"},{"name":"Department of Biology, Faculty of Life and Natural Sciences Laboratory of Biology, Environment and Health, Echahid Hamma Lakhdar University  El Oued Algeria"},{"name":"Laboratory of the Development and Technology of Saharan Resources (VTRS), Echahid Hamma Lakhdar El Oued University  El Oued Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nourelhouda","family":"Mekhadmi","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Nature and Life Sciences University of El Oued  El Oued Algeria"},{"name":"Laboratory of the Development and Technology of Saharan Resources (VTRS), Echahid Hamma Lakhdar El Oued University  El Oued Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randa","family":"Mlik","sequence":"additional","affiliation":[{"name":"National Institute of Agronomic Research of Algeria, INRAA  Adrar Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8403-566X","authenticated-orcid":false,"given":"Asma","family":"Abid","sequence":"additional","affiliation":[{"name":"Faculty of Mathematics and Matter Sciences, Laboratory of Valorization and Promotion of Saharan Resources, University of Ouargla  Ouargla Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elyes","family":"Kelai","sequence":"additional","affiliation":[{"name":"Scientific and Technical Research Center in Physico\u2010Chemical Analysis (CRAPC)  Tipaza Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Boussebaa","sequence":"additional","affiliation":[{"name":"Scientific and Technical Research Center in Physico\u2010Chemical Analysis (CRAPC)  Tipaza Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aicha","family":"Mouane","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Nature and Life Sciences University of El Oued  El Oued Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Selmane","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Nature and Life Sciences University of El Oued  El Oued Algeria"},{"name":"Department of Biology, Faculty of Life and Natural Sciences Laboratory of Biology, Environment and Health, Echahid Hamma Lakhdar University  El Oued Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoual","family":"Zemmouli","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Nature and Life Sciences University of El Oued  El Oued Algeria"},{"name":"Department of Biology, Faculty of Life and Natural Sciences Laboratory of Biology, Environment and Health, Echahid Hamma Lakhdar University  El Oued Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohnad","family":"Abdalla","sequence":"additional","affiliation":[{"name":"Pediatric Research Institute, Children's Hospital Affiliated to Shandong University  Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr Ahmed","family":"El\u2010Arabey","sequence":"additional","affiliation":[{"name":"Applied College, King Khalid University  Abha Saudi Arabia"},{"name":"Center of Bee Research and its Products, King Khalid University  Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romisa","family":"Mamoun","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science and Technology, Tianjin University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghamam\u2010Amara","family":"Djilani","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Nature and Life Sciences University of El Oued  El Oued Algeria"},{"name":"Department of Biology, Faculty of Life and Natural Sciences Laboratory of Biology, Environment and Health, Echahid Hamma Lakhdar University  El Oued Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Munir","sequence":"additional","affiliation":[{"name":"Date Palm Research Center of Excellence, King Faisal University  Al\u2010Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2542-5196(22)00317-5"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.9734\/ijecc\/2024\/v14i23931"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23040762"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-37424-1_6"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stress.2023.100255"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.32604\/phyton.2019.07559"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jse.12649"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42729-022-01062-w"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1051\/agro:19860611"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envexpbot.2005.12.006"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtb.2016.08.009"},{"key":"e_1_2_12_13_1","article-title":"The Biochemical Properties of Satureja Speciesaffected by Micronutrients, Genotype, and Locations in Drought Stress Conditions","author":"Taba A. B.","year":"2024","journal-title":"Journal of the Saudi Society of Agricultural Sciences"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118252"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114447"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305-1978(87)90060-3"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.111841"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2020.104019"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.11.028"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1603\/EC10318"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2021.102300"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/19476337.2024.2337001"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.15586\/ijfs.v36i3.2627"},{"key":"e_1_2_12_24_1","volume-title":"Soil Chemical Analysis: Advanced Course: A Manual of Methods Useful for Instruction and Research in Soil Chemistry, Physical Chemistry of Soils, Soil Fertility, and Soil Genesis","author":"Jackson M. L.","year":"2005"},{"key":"e_1_2_12_25_1","unstructured":"A.Juo Selected Methods for Soiland Plant Analysis: IITA Manual Series No. 1.1978."},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)65988-5"},{"key":"e_1_2_12_27_1","first-page":"641","article-title":"DerEinflus hoher Salzkonzentrationen auf verschiedene physiologische Parameter","volume":"23","author":"Dreier W.","year":"1974","journal-title":"Wissenschaftliche Zeitschrift Der Humboldt\u2010Universit\u00e4t Berlin"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac60111a017"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02374789"},{"key":"e_1_2_12_30_1","first-page":"606X","article-title":"Spectrophotometric Analysis of Chlorophylls and Carotenoids From Commonly Grown Fern Species by Using Various Extracting Solvents","volume":"2231","author":"Sumanta N.","year":"2014","journal-title":"Research Journal of Chemical Sciences"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2006.03.045"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.52711\/0974-360X.2022.00564"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1515\/chem-2024-0087"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2008.02.037"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114937"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1999.4019"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.22270\/jddt.v10i2-s.4022"},{"key":"e_1_2_12_38_1","volume-title":"Bact\u00e9riologie G\u00e9n\u00e9rale et M\u00e9dicale (Ellipses)","author":"Fauch\u00e8re J.\u2010L.","year":"2002"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.4103\/0250-474X.108420"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20289"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-023-02140-4"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026623666230106121527"},{"key":"e_1_2_12_43_1","unstructured":"A.Kalla D.Belkacemi N.Gherraf et\u00a0al. Seasonal Variability of Essential Oil Content of Pituranthos Scoparius.2010."},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v16i1.7"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfpp.13163"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X1100600828"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201800149"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10298-015-0932-4"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcab.2024.103306"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13596-016-0253-7"},{"key":"e_1_2_12_51_1","first-page":"1","article-title":"Phytochemical Screening, Antioxidant Activities and Hemolytic Power of Four Saharan Plants From Algeria","author":"Haddouchi F.","year":"2016","journal-title":"Phytoth\u00e9rapie"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113488"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.31080\/ASNH.2022.06.1015"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.132531"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2014.07.001"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2011.00573.x"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.2174\/1872213X10666160711143904"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00380"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11020135"},{"key":"e_1_2_12_60_1","first-page":"1","article-title":"Variation of Essential Oils Composition of Pituranthos scoparius in Algeria","volume":"2","author":"Lograda T.","year":"2013","journal-title":"Global Journal of Research on Medicinal Plants & Indigenous Medicine"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.5958\/j.0975-4261.3.2.030"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2007-7-808"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4962707"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hermed.2016.11.003"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.4314\/bcse.v37i4.17"},{"key":"e_1_2_12_66_1","first-page":"2165","article-title":"Phenolic Profile: Antimicrobial activity and Antioxidant Capacity of Colocasia esculenta (L.) Schott","volume":"64","author":"Elmosallamy A.","year":"2021","journal-title":"Egyptian Journal of Chemistry"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbl2809229"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiosc.2014.01.001"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/scipharm90040057"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2005.06.015"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.47583\/ijpsrr.2021.v69i02.002"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600-005-0053-7"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.4236\/abc.2015.57024"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcab.2020.101844"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202500643","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202500643","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202500643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:57:08Z","timestamp":1773010628000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202500643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,9]]},"references-count":73,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/cbdv.202500643"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202500643","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,9]]},"assertion":[{"value":"2025-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202500643"}}