{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T04:29:05Z","timestamp":1783744145871,"version":"3.55.0"},"reference-count":81,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Herbs belonging to the Zingiberaceae family are frequently utilized in traditional medicine. Nevertheless, there has yet to be a study that thoroughly examines the biological properties of Zingiberaceae rhizomes while also conducting a chemometric analysis of their metabolic components. The present study explored the total phenolic content, antioxidant, antidiabetic, and antibacterial activity of <jats:italic>Curcuma xanthorrhiza<\/jats:italic>, <jats:italic>Zingiber officinale<\/jats:italic>, <jats:italic>Alpinia galanga<\/jats:italic>, <jats:italic>Kaempferia galanga<\/jats:italic>, and <jats:italic>Curcuma domestica<\/jats:italic> concurrent with chemometric analysis of their metabolic components. The highest antioxidant activity measured using DPPH (2,2\u2010diphenyl\u20101\u2010picryl\u2010hydrazyl) assay was found in <jats:italic>Z. officinale<\/jats:italic> extract (IC<jats:sub>50<\/jats:sub>\u00a0=\u00a014.93\u00a0\u00b5g\/mL), followed by <jats:italic>C. domestica<\/jats:italic> extract (IC<jats:sub>50<\/jats:sub>\u00a0=\u00a035.56\u00a0\u00b5g\/mL). Moreover, all samples demonstrated in vitro antidiabetic activity by inhibiting \u03b1\u2010glucosidase, with <jats:italic>C. domestica<\/jats:italic> showing the highest activity (98.42%), followed by <jats:italic>K. galanga<\/jats:italic> (86.13%), <jats:italic>A. galanga<\/jats:italic> (85.04%), <jats:italic>Z. officinale<\/jats:italic> (74.76%), and <jats:italic>C. xanthorrhiza<\/jats:italic> (43.74%). All extracts exhibited antibacterial activity against <jats:italic>Staphylococcus aureus, Salmonella typhimurium, Escherichia coli, Bacillus subtilis<\/jats:italic>, and <jats:italic>Pseudomonas aeruginosa<\/jats:italic>, with <jats:italic>C. domestica<\/jats:italic> and <jats:italic>C. xanthorrhiza<\/jats:italic> extracts being the most active extracts at a concentration of 5\u00a0mg\/mL. Fourier\u2010transform infrared (FTIR) spectra supported the presence of phenolic compounds in all extracts. In addition, liquid chromatography\u2013high\u2010resolution mass spectrometry (LC\u2013HRMS) analysis revealed various compounds in the extracts, including phenolic compounds, flavonoids, aldehyde, fatty amide, amino acid, fatty acid, ketone, purine derivative, and glycosides. Partial least square\u2010discriminant analysis (PLS\u2010DA) successfully discriminated <jats:italic>C. xanthorrhiza<\/jats:italic>, <jats:italic>Z. officinale<\/jats:italic>, <jats:italic>A. galanga<\/jats:italic>, <jats:italic>K. galanga<\/jats:italic>, and <jats:italic>C. domestica<\/jats:italic> extracts based on their different metabolite composition. This study revealed the potency of <jats:italic>C. xanthorrhiza<\/jats:italic>, <jats:italic>Z. officinale<\/jats:italic>, <jats:italic>A. galanga<\/jats:italic>, <jats:italic>K. galanga<\/jats:italic>, and <jats:italic>C. domestica<\/jats:italic> as natural sources packed with antioxidant, antidiabetic, and antibacterial benefits in functional food and pharmaceutical products.<\/jats:p>","DOI":"10.1002\/cbdv.202500645","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T21:04:07Z","timestamp":1747861447000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of the Antioxidant, Antidiabetic, and Antibacterial Activity of <i>Curcuma domestica, Zingiber officinale, Alpinia galanga, Curcuma xanthorrhiza<\/i>, and <i>Kaempferia galanga<\/i> Concurrent With Its Metabolite's Constituent Analysis"],"prefix":"10.1002","author":[{"given":"Anjar","family":"Windarsih","sequence":"first","affiliation":[{"name":"Research Center for Food Technology and Processing National Research and Innovation Agency (BRIN)  Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7073-2421","authenticated-orcid":false,"given":"Anastasia Wheni","family":"Indrianingsih","sequence":"additional","affiliation":[{"name":"Research Center for Food Technology and Processing National Research and Innovation Agency (BRIN)  Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ria","family":"Suryani","sequence":"additional","affiliation":[{"name":"Research Center for Food Technology and Processing National Research and Innovation Agency (BRIN)  Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tri","family":"Wiyono","sequence":"additional","affiliation":[{"name":"Research 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