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Accordingly, the present study selected 28 multimodal phytochemicals (P1 to P28) and further assessed their potency and drug\u2010ability using computer\u2010aided drug design (CADD) and experimental methods. At first, the putative targets for OLP were selected through network pharmacology, and then molecular docking scores with predicted drug\u2010ability profiles recommended that P12 (epicatechin gallate\/ECG) be the lead candidate among all. Furthermore, the protein\u2013ligand stability of ECG against the nonsteroidal target cyclooxygenase\u20102 (COX\u20102) and the steroidal target glucocorticoid receptor (GR) was investigated using molecular dynamics (MD) simulations over 200\u00a0ns, and free energy calculations (MM\/PBSA) were performed with GROMACS\u20102020 software. The nontoxic dose for ECG was observed to be &gt;\u00a0100\u00a0\u00b5M in three cell lines (HEK293, Huh7, and THP\u20101). The gene expression results demonstrated that the COX\u20102 and the proinflammatory cytokine IL\u20101\u03b2 significantly reduced, and the anti\u2010inflammatory cytokine IL\u201010 slightly increased in a concentration\u2010dependent manner in inflammation\u2010induced (LPS\u2010treated) THP\u20101 cells. Overall, the systematic computational and experimental results suggested that ECG could be a potent therapeutic option for managing OLP among the listed treatments.<\/jats:p>","DOI":"10.1002\/cbdv.202500662","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T16:20:21Z","timestamp":1750090821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Anti\u2010Inflammatory and Immunomodulatory Phytochemicals for Management of Oral Lichen Planus: A Multi\u2010Omics System Biology and Experimental Assessment"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6743-3885","authenticated-orcid":false,"given":"Alaka","family":"Sahoo","sequence":"first","affiliation":[{"name":"Department of Skin &amp; VD Institute of Medical Sciences and SUM Hospital Siksha \u2018O\u2019 Anusandhan Deemed to be University  Bhubaneswar Odisha India"},{"name":"Department of Pharmaceutical 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