{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:39:21Z","timestamp":1773013161669,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014952","name":"Direktorat Jenderal Penguatan Riset dan Pengembangan","doi-asserted-by":"publisher","award":["60\/UN11.L1\/PG.01.03\/DPPM\/2025"],"award-info":[{"award-number":["60\/UN11.L1\/PG.01.03\/DPPM\/2025"]}],"id":[{"id":"10.13039\/501100014952","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this study, a comprehensive chemical profiling of\n                    <jats:italic>Cymbopogon citratus<\/jats:italic>\n                    metabolites grown in Aceh, Indonesia, was performed by UHPLC\u2013ESI\u2013QTOF\u2013MS\/MS on its 80% ethanol extract, and GC\u2013MS on its hydrodistilled essential oil. The samples were also investigated for their anti\u2010inflammatory activity through bovine serum albumin (BSA) protein denaturation inhibition and human red blood cell (HRBC) membrane stabilization techniques. LC\u2013MS\/MS analysis of the extract putatively identified 54 compounds, represented by 23 phenolic compounds (flavonoids, flavonoid glycosides, lignans, anthraquinone glycosides, coumarins, and a phenolic acid), 7 carboxylic acids and esters, 7 carbohydrates, 5 amino acids, 5 lipids, 2 steroids, 2 lactones, 2 alkaloids, and 1 monoterpenoid. GC\u2013MS analysis of the essential oil indicated it was mainly made up of monoterpenoids with neral (25.89%) and geranial (49.97%) as the major compounds. The chemical contents identified in the extract and essential oil of the plant grown in Aceh were qualitatively and quantitatively different from samples reported elsewhere. Both extract and essential oil exhibited anti\u2010inflammatory activity by stabilizing the HRBC membrane against hypotonicity\u2010induced hemolysis and inhibited the BSA protein denaturation in a concentration\u2010dependent manner. The anti\u2010inflammatory activity of\n                    <jats:italic>C. citratus<\/jats:italic>\n                    was attributed mainly to the presence of bioactive compounds especially phenolic compounds and monoterpenoids.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500668","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T11:34:22Z","timestamp":1750419262000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comprehensive UHPLC\u2013MS\/MS and GC\u2013MS Metabolite Profiling and Anti\u2010Inflammatory Effect of the Ethanol Extract and Essential Oil of\n                    <i>Cymbopogon citratus<\/i>\n                    (DC.) Staph Grown in Aceh, Indonesia"],"prefix":"10.1002","volume":"22","author":[{"given":"Irma","family":"Sari","sequence":"first","affiliation":[{"name":"Graduate School of Mathematics and Applied Sciences Universitas Syiah Kuala  Banda Aceh Indonesia"},{"name":"Department of Pharmacy Universitas Syiah Kuala  Banda Aceh Indonesia"},{"name":"Halal Research Center Universitas Syiah Kuala  Banda Aceh Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1595-2165","authenticated-orcid":false,"given":"Mustanir","family":"Yahya","sequence":"additional","affiliation":[{"name":"Department of Chemistry Universitas Syiah Kuala  Banda Aceh Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9066-4780","authenticated-orcid":false,"given":"Ibrahim","family":"Jantan","sequence":"additional","affiliation":[{"name":"Institute of Systems Biology (INBIOSIS) Universiti Kebangsaan Malaysia  UKM Bangi Selangor Malaysia"},{"name":"Faculty of Pharmacy Universitas Sumatera Utara  Medan Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4585-5817","authenticated-orcid":false,"given":"Binawati","family":"Ginting","sequence":"additional","affiliation":[{"name":"Department of Chemistry Universitas Syiah Kuala  Banda Aceh Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Elfahmi","sequence":"additional","affiliation":[{"name":"School of Pharmacy Bandung Institute of Technology  Bandung Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4367-522X","authenticated-orcid":false,"given":"Marissa","family":"Angelina","sequence":"additional","affiliation":[{"name":"Research Center for Pharmaceutical Ingredients and Traditional Medicine National Research and Innovation Agency (BRIN), Cibinong Science Center (CSC)  Bogor West Java Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5888-9004","authenticated-orcid":false,"given":"Hilda","family":"Maysarah","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Universitas Syiah Kuala  Banda Aceh Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prenap.2024.100046"},{"key":"e_1_2_9_3_1","first-page":"1035","article-title":"Potential Functions of Lemon Grass (Cymbopogon citratus) in Health and Disease","volume":"3","author":"Nambiar V.","year":"2012","journal-title":"International Journal of Pharmaceutical & Biological Archives"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sciaf.2019.e00137"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20057438"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5455\/2319-2003.ijbcp20140817"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.603858"},{"issue":"1","key":"e_1_2_9_8_1","first-page":"1","article-title":"Chemical Composition and Biological Activities of Essential Oil From Turmeric (Curcuma longa L.) 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