{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:40:22Z","timestamp":1773013222807,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In the search for new antimicrobial agents, this study investigated the phytochemical composition of the aerial parts of\n                    <jats:italic>Jatropha integerrima<\/jats:italic>\n                    , leading to the isolation of two new myrsinane\u2010type diterpenoids, jatrophodiones F and G (\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>2<\/jats:bold>\n                    ), along with seven known compounds: jatrointelone A (\n                    <jats:bold>3<\/jats:bold>\n                    ), \u03b1\u2010tocospiro A (\n                    <jats:bold>4<\/jats:bold>\n                    ), 8(14),15\u2010sandaracopimaradien\u20103\u03b2\u2010ol (\n                    <jats:bold>5<\/jats:bold>\n                    ), curdione (\n                    <jats:bold>6<\/jats:bold>\n                    ), 5\u03b1,8\u03b1\u2010epidioxyergosta\u20106,9(11),22\u2010trien\u20103\u03b2\u2010ol (\n                    <jats:bold>7<\/jats:bold>\n                    ), 7\u2010oxo\u2010\u03b2\u2010sitosterol (\n                    <jats:bold>8<\/jats:bold>\n                    ), and 3\u03b2\u2010hydroxystigmast\u20105(6),22\u2010diene\u20107\u2010one (\n                    <jats:bold>9<\/jats:bold>\n                    ). The structures of these compounds were elucidated via high\u2010resolution electrospray ionization time\u2010of\u2010flight mass spectrometry and infrared, ultraviolet, and nuclear magnetic resonance spectroscopy, comparing the analyses with reported spectroscopic data. Compounds\n                    <jats:bold>1\u20133<\/jats:bold>\n                    and\n                    <jats:bold>5<\/jats:bold>\n                    \u2013\n                    <jats:bold>9<\/jats:bold>\n                    exhibited moderate to strong activity against eight microorganisms, including\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    ,\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    ,\n                    <jats:italic>Enterococcus faecalis<\/jats:italic>\n                    ,\n                    <jats:italic>Bacillus cereus<\/jats:italic>\n                    ,\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ,\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    , and\n                    <jats:italic>Aspergillus brasiliensis<\/jats:italic>\n                    , with minimum inhibitory concentrations (MICs) ranging from 32 to 256\u00a0\u00b5g\/mL. On the other hand, compound\n                    <jats:bold>4<\/jats:bold>\n                    inhibited only three tested Gram\u2010positive bacterial strains and two fungi, with MICs varying from 64 to 128\u00a0\u00b5g\/mL. This study is the first to investigate the antimicrobial activity of myrsinane\u2010type diterpenoids (\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>2<\/jats:bold>\n                    ) and provides new insights into the potential therapeutic applications of these compounds.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500671","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T19:10:20Z","timestamp":1752779420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Two New Myrsinane\u2010type Diterpenoids From the Aerial Parts of\n                    <i>Jatropha integerrima<\/i>\n                    Jacq. and Their Antimicrobial Activity"],"prefix":"10.1002","volume":"22","author":[{"given":"Hanh Nhu Thi","family":"Hoang","sequence":"first","affiliation":[{"name":"Faculty of Engineering and Food Technology Hue University of Agriculture and Forestry Hue University  Hue City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le Thanh","family":"Long","sequence":"additional","affiliation":[{"name":"Faculty of Engineering and Food Technology Hue University of Agriculture and Forestry Hue University  Hue City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le Thu","family":"Ha","sequence":"additional","affiliation":[{"name":"Faculty of Engineering and Food Technology Hue University of Agriculture and Forestry Hue University  Hue City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vu Thi Thanh","family":"Tam","sequence":"additional","affiliation":[{"name":"Mientrung Institute for Scientific Research Vietnam National Museum of Nature, Vietnam Academy of Science and Technology  Hue City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ton That Huu","family":"Dat","sequence":"additional","affiliation":[{"name":"Mientrung Institute for Scientific Research Vietnam National Museum of Nature, Vietnam Academy of Science and Technology  Hue City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuong Viet Canh","family":"Le","sequence":"additional","affiliation":[{"name":"Mientrung Institute for Scientific Research Vietnam National Museum of Nature, Vietnam Academy of Science and Technology  Hue City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hieu","family":"Le Trung","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry Hue University of Sciences Hue University  Hue City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao Chi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Science, Technology &amp; International Relations Hue University  Hue City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoai Thi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Hue University of Medicine and Pharmacy, Hue University  Hue City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7442-3925","authenticated-orcid":false,"given":"Duc Viet","family":"Ho","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Hue University of Medicine and Pharmacy, Hue University  Hue City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"J.O'Neill.Tackling Drug\u2010Resistant Infections Globally: Final Report and Recommendation. 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