{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:36:20Z","timestamp":1787013380369,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Five novel dimeric polyketides, citrifuran E\u2013I (<jats:bold>1<\/jats:bold>\u2013<jats:bold>5<\/jats:bold>), were isolated from the fungus <jats:italic>Aspergillus<\/jats:italic> sp. AWG 1\u201315. These polyketides were rare heterodimers of azaphilone and furanone derivatives. Their relative and absolute configurations were determined based on high\u2010resolution electrospray ionization mass spectrometry and spectroscopic analyses (one\u2010 and two\u2010dimensional nuclear magnetic resonance), electronic circular dichroism calculations, and chemical derivatization. All compounds were assessed for anti\u2010inflammatory activity by measuring their effects on nitric oxide production induced by lipopolysaccharide in RAW 264.7 cells. Compounds <jats:bold>1\u20134<\/jats:bold> exhibited moderate inhibitory activity, with the minimum inhibitory concentration (IC<jats:sub>50<\/jats:sub>) values ranging from 12.6 to 37.3 \u00b5M, compared to the positive control <jats:italic>N<\/jats:italic><jats:sup>G<\/jats:sup>\u2010monomethyl\u2010<jats:italic>L<\/jats:italic>\u2010arginine (IC<jats:sub>50<\/jats:sub> = 40.6 \u00b5M).<\/jats:p>","DOI":"10.1002\/cbdv.202500695","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T13:54:53Z","timestamp":1744034093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Citrifuran E\u2013I, Five Dimeric Polyketides With Potential Anti\u2010inflammatory Activity From <i>Aspergillus<\/i> sp. AWG 1\u201315"],"prefix":"10.1002","author":[{"given":"Qun\u2010Yan","family":"Jiang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy China Pharmaceutical University Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Ping","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy China Pharmaceutical University Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy China Pharmaceutical University Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy China Pharmaceutical University Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9712-2618","authenticated-orcid":false,"given":"Ling\u2010Yi","family":"Kong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy China Pharmaceutical University Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6063-8397","authenticated-orcid":false,"given":"Ming\u2010Hua","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy China Pharmaceutical University Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41579-021-00620-w","article-title":"From the Soil to the Clinic: The Impact of Microbial Secondary Metabolites on Antibiotic Tolerance and Resistance","volume":"20","author":"Perry E. 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