{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:48:26Z","timestamp":1790729306201,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n This study discussed the synthesis of novel [1,2,4]triazolo[3,4\u2010\n a<\/jats:italic>\n ]isoquinolines and 5,6\u2010dihydropyrrolo[2,1\u2010\n a<\/jats:italic>\n ]isoquinolines as promising antibacterial agents, showing the significance of isoquinoline scaffold to enhance these biological activities. [1,2,4]Triazolo[3,4\u2010\n a<\/jats:italic>\n ]isoquinolines\n 6\u20138<\/jats:bold>\n and 5,6\u2010dihydropyrrolo[2,1\u2010\n a<\/jats:italic>\n ]isoquinolines\n 9<\/jats:bold>\n ,\n 10<\/jats:bold>\n were obtained by the reaction of hydrazonoyl chlorides\n 3\u20135<\/jats:bold>\n with 6,7\u2010dimethoxy\u20103,4\u2010dihydroisoquinolines\n 1a<\/jats:bold>\n ,\n b<\/jats:bold>\n and ethyl 2\u2010(6,7\u2010dimethoxy\u20103,4\u2010dihydroisoquinolin\u20101\u2010yl)acetate\n 2<\/jats:bold>\n , respectively, in chloroform in the presence of triethylamine. Utility of [1,2,4]triazolo[3,4\u2010\n a<\/jats:italic>\n ]isoquinolines\n 6a<\/jats:bold>\n in the synthesis of enamoinone\n 11<\/jats:bold>\n , [1,2,4]triazolo[3,4\u2010\n a<\/jats:italic>\n ]isoquinolin\u2010pyrazoles\n 13a\u2013e,<\/jats:bold>\n and chalcones\n 21a\u2013g<\/jats:bold>\n . Following structural confirmation\n via<\/jats:italic>\n spectral data, the newly synthesized compounds were evaluated for antibacterial efficacy against two Gram\u2010positive and two Gram\u2010negative bacterial strains. The findings revealed that compounds\n 6a<\/jats:bold>\n and\n 8a<\/jats:bold>\n exhibited significant antibacterial activity against\n Salmonella<\/jats:italic>\n , with inhibition zones measuring 23 and 18\u00a0mm, respectively. In contrast, compounds\n 7a<\/jats:bold>\n and\n 13e<\/jats:bold>\n demonstrated notable activity against\n E. coli<\/jats:italic>\n , showing inhibition zones of 13 and 27\u00a0mm, respectively, while compound\n 13d<\/jats:bold>\n was effective against\n Listeria monocytogenes<\/jats:italic>\n with a 12\u00a0mm inhibition zone. The remaining compounds displayed no observable antibacterial properties. Molecular docking simulations were performed for the most active compounds,\n 13d<\/jats:bold>\n and\n 13e<\/jats:bold>\n , supporting their potential as promising inhibitors. Compound\n 13e<\/jats:bold>\n was identified as a potential inhibitor of\n E. coli<\/jats:italic>\n DNA gyrase subunit B (P0AES6), while compound\n 13d<\/jats:bold>\n showed inhibitory potential against transglycosylases of\n L. monocytogenes<\/jats:italic>\n (A0A0E1R719).\n <\/jats:p>","DOI":"10.1002\/cbdv.202500703","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T14:16:54Z","timestamp":1751897814000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synthesis, Spectral Characterization, and Biological Evaluation of Novel [1,2,4]Triazolo[3,4\u2010\n a<\/i>\n ]isoquinolines and 5,6\u2010Dihydropyrrolo[2,1\u2010\n a<\/i>\n ]isoquinolines: Insights From Molecular Docking, ADMET, and Antibacterial Studies"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5992-3519","authenticated-orcid":false,"given":"Yara N.","family":"Laboud","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science Cairo University Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A. Mohamed","family":"Teleb","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Cairo University Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doaa","family":"Zahran","sequence":"additional","affiliation":[{"name":"Depatment of Botany and Microbiology, Faculty of Science Cairo University Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0963-4192","authenticated-orcid":false,"given":"Hamdi M.","family":"Hassaneen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Cairo University Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0451-4802","authenticated-orcid":false,"given":"Fatma M.","family":"Saleh","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Cairo University Giza 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