{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:12:05Z","timestamp":1788779525849,"version":"build-2803163510"},"reference-count":78,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Bioenhancers are compounds derived from herbal sources that enhance the bioavailability of pharmaceutical drugs, thereby improving their effectiveness and reducing the required dosage. These bioenhancers are becoming increasingly important in modern pharmacology for their ability to optimize drug delivery and minimize the side effects. This review explores the basics of bioenhancers, their classification, significance, mechanisms of action, benefits, challenges, and potentials in various applications of drug delivery. The review aims to identify and discuss the advantages and limitations of bioenhancers, evaluate current research trends, and outline the future prospects for integrating these compounds. Herbal bioenhancers enhance the bioavailability of pharmaceutical drugs by improving absorption, modulating drug metabolism, and interacting with drug transporters. Key examples include piperine, which inhibits CYP3A4 and P\u2010glycoprotein to boost drug plasma levels; quercetin, which modulates Phase II enzymes and transporters; curcumin, which enhances intestinal absorption through membrane fluidity alteration, and so forth. These mechanisms lead to improved therapeutic outcomes and reduced drug dosage. Despite their promise, challenges such as variability in herbal composition, regulatory concerns, and potential drug\u2013herb interactions persist. Recent innovations such as nanoformulations, lipid\u2010based carriers, and targeted delivery systems are actively addressing these barriers by enhancing stability, specificity, and efficacy. Data for this review were sourced from comprehensive searches of academic databases, including ScienceDirect, PubMed, and Google Scholar. Relevant literature was identified using search terms such as \u201cherbal bioenhancers,\u201d \u201cmechanisms of action,\u201d \u201cdrug delivery systems,\u201d and \u201cphytochemicals.\u201d Studies, clinical trials, and recent research articles were reviewed to gather information on the efficacy, applications, and challenges associated with herbal bioenhancers. Current research is addressing these issues through innovative formulations and clinical trials. The scope of this review includes an examination of current knowledge on herbal bioenhancers and their application in drug delivery. The future of herbal bioenhancers is promising, with potential advancements in discovering new compounds, understanding their mechanisms, and applying personalized medicine approaches. Ongoing research is expected to resolve existing challenges and further integrate herbal bioenhancers into drug therapies, enhancing their effectiveness and safety in future pharmaceutical applications.<\/jats:p>","DOI":"10.1002\/cbdv.202500760","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T06:44:47Z","timestamp":1744353887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Herbal Bioenhancers in Pharmaceutical Drug Delivery: Mechanisms, Challenges, and Future Innovations"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1257-723X","authenticated-orcid":false,"given":"Bina","family":"Gidwani","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Quality Assurance Columbia Institute of Pharmacy  Raipur Chhattisgarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Bhairam","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics Columbia Institute of Pharmacy  Raipur Chhattisgarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv Shankar","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Quality Assurance Columbia Institute of Pharmacy  Raipur Chhattisgarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsh","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Columbia Institute of Pharmacy  Raipur Chhattisgarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8284-6269","authenticated-orcid":false,"given":"Ravindra Kumar","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Columbia Institute of Pharmacy  Raipur Chhattisgarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.123734"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods13111681"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229\u2010516x.81972"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.4172\/2153\u20102435.1000591"},{"key":"e_1_2_17_6_1","first-page":"1","article-title":"Bioenhancers\u00a0: A Brief Review Bioenhancers\u00a0: A Brief Review","volume":"5","author":"Chivte V. 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