{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:03:20Z","timestamp":1789578200221,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Antineoplastic agents can induce tissue damage through oxidative stress mechanisms. Doxorubicin, a widely used chemotherapeutic agent, has been shown to cause permanent damage to reproductive tissues. Antioxidant\u2010rich dietary interventions are considered a promising approach to mitigate oxidative stress\u2010related damage. This study aimed to evaluate the therapeutic potential of an antioxidant\u2010rich bee product mixture (ARPM) in ameliorating doxorubicin\u2010induced ovarian injury. The ARPM, composed of honey, pollen, propolis, and royal jelly, was administered via gavage to female Sprague\u2010Dawley rats (180\u2013200\u00a0g) following chronic ovarian damage induced by doxorubicin (6\u00a0mg\/kg, ip). Oxidative stress markers, including superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione (GSH), as well as endoplasmic reticulum (ER) stress\u2010related markers such as 78\u2010kDa glucose\u2010regulated protein (GRP78), inositol\u2010requiring enzyme 1 (IRE1), C\/EBP homologous protein (CHOP), tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), and caspase\u20103, were simultaneously evaluated. In addition, estradiol (E2) and progesterone levels were measured, and histopathological evaluations were conducted. The mixture, rich in bioactive compounds including chrysin, pinocembrin, caffeic acid, ferulic acid, and coumaric acid, was found to significantly improve ovarian function by reducing ER stress compared to the control group. These findings suggest that ARPM may offer protective effects against doxorubicin\u2010induced ovarian damage through its antioxidative and anti\u2010ER stress properties.<\/jats:p>","DOI":"10.1002\/cbdv.202500766","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T18:14:41Z","timestamp":1753208081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bee\u2010Derived Antioxidants as a Protective Strategy Against Doxorubicin\u2010Induced Ovarian Damage"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8652-941X","authenticated-orcid":false,"given":"Meltem Ar\u0131kan","family":"Malkoc","sequence":"first","affiliation":[{"name":"Vocational School of Health Sciences Karadeniz Technical University  Trabzon 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