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Both natural and synthetic compounds from this group are increasingly studied for their potential in skin depigmentation. Hyperpigmentation disorders such as melasma, freckles, lentigines, and post\u2010inflammatory or hormonal pigmentation are common aesthetic concerns that remain difficult to treat effectively. Several cinnamic acid derivatives, including plant extracts containing these compounds, have shown promise as melanogenesis inhibitors. Notably, piperlongumine has already been registered as a cosmetic skin\u2010lightening agent. Natural compounds like ferulic acid and chlorogenic acid are used in formulations for their multifunctional benefits to skin appearance and condition. Synthetic derivatives, particularly esters and amides, have also demonstrated potent anti\u2010melanogenic activity. Interestingly, these effects may occur independently of antioxidant mechanisms. Reliable evidence supporting the efficacy of these compounds comes from advances in vitro models, such as 3D cell cultures and pigmented reconstructed human epidermis. However, clinical confirmation remains limited. To date,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010coumaric acid and extracts from bird's nest fern and pomegranate peel have been clinically evaluated. Current literature supports the continued exploration of cinnamic acid derivatives as promising candidates for cosmetic products targeting skin hyperpigmentation.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500767","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T19:39:54Z","timestamp":1755545994000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cinnamic Acid Derivatives as Potential Melanogenesis Inhibitors for Use in Cosmetic Products"],"prefix":"10.1002","volume":"22","author":[{"given":"Ma\u0142gorzata","family":"Kabat","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Jagiellonian University Medical College  Krakow Poland"},{"name":"Doctoral School of Medical and Health Sciences Jagiellonian University Medical College  Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4162-4760","authenticated-orcid":false,"given":"Agnieszka","family":"Gunia\u2010Krzy\u017cak","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Jagiellonian University Medical College  Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"\u201cCosIng\u2014Cosmetics Ingredients; Ingredient: Cinnamic acid \u201dhttps:\/\/ec.europa.eu\/growth\/tools\u2010databases\/cosing\/details\/75367."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14166"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2019.100010"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12471"},{"key":"e_1_2_11_6_1","unstructured":"\u201cCommission Regulation (EU) 2023\/1490 of 19 July 2023 Amending Regulation (EC) No 1223\/2009 Anex VI List of UV Filters Allowed in Cosmetic Products \u201dhttps:\/\/ec.europa.eu\/growth\/tools\u2010databases\/cosing\/reference\/annexes\/list\/VI."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics10040101"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29235806"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22020281"},{"key":"e_1_2_11_10_1","unstructured":"\u201cCosIng\u2014Cosmetic Ingredients; Ingredient: Ferulic Acid \u201dhttps:\/\/ec.europa.eu\/growth\/tools\u2010databases\/cosing\/details\/33935."},{"key":"e_1_2_11_11_1","unstructured":"\u201cCosIng\u2014Cosmetics Ingredients; Ingredient: Caffeic Acid \u201dhttps:\/\/ec.europa.eu\/growth\/tools\u2010databases\/cosing\/details\/55168."},{"key":"e_1_2_11_12_1","unstructured":"\u201cCosIng\u2014Cosmetics Ingredients; Ingredient:p\u2010Coumaric Acid \u201dhttps:\/\/ec.europa.eu\/growth\/tools\u2010databases\/cosing\/details\/34490."},{"key":"e_1_2_11_13_1","unstructured":"\u201cCosIng\u2014Cosmetics Ingredients; Ingredient: Sinapic Acid \u201dhttps:\/\/ec.europa.eu\/growth\/tools\u2010databases\/cosing\/details\/88992."},{"key":"e_1_2_11_14_1","unstructured":"\u201cCosIng\u2014Cosmetics Ingredients; Ingredient: Rosmarinic Acid \u201dhttps:\/\/ec.europa.eu\/growth\/tools\u2010databases\/cosing\/details\/37536."},{"key":"e_1_2_11_15_1","unstructured":"\u201cCosIng\u2014Cosmetics Ingredients; Ingredient: Chlorogenic Acids \u201dhttps:\/\/ec.europa.eu\/growth\/tools\u2010databases\/cosing\/details\/74986."},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/138955712801264792"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13070853"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666201020163331"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2021.02.064"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570180815666180420105652"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24098226"},{"key":"e_1_2_11_22_1","unstructured":"\u201cCosIng\u2014Cosmetics Ingredients; Ingredient: Piperlongumine \u201dhttps:\/\/ec.europa.eu\/growth\/tools\u2010databases\/cosing\/details\/88740."},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28124839"},{"key":"e_1_2_11_24_1","first-page":"1955","article-title":"Common Hyperpigmentation Disorders in Adults: Part I. 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