{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:32:50Z","timestamp":1782484370919,"version":"3.54.5"},"reference-count":61,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic kidney disease (CKD) presents a significant global health concern, often leading to complications such as renal failure and cardiovascular issues. Alternative therapies based on medicinal plants are the focused area for the management of CKD. The present study focuses on the impact of\n                    <jats:italic>Vetiveria zizanioides<\/jats:italic>\n                    extract and its terpenes\u2010rich oil in management of CKD. The study was carried out in 0.3% of adenine\u2010induced CKD in\n                    <jats:italic>Sprague Dawley<\/jats:italic>\n                    rats. Animals were divided into seven groups (\n                    <jats:italic>n<\/jats:italic>\n                    = 8), including normal control, disease control, standard control (dapagliflozin 10\u00a0mg\/kg), extract treatment groups (250 and 500\u00a0mg\/kg), and oil treatment groups (50 and 100\u00a0mg\/kg). Treatment of\n                    <jats:italic>Vetiveria zizanioides<\/jats:italic>\n                    extract and terpene\u2010rich oil was given orally for 28 days after induction of the CKD. Biochemical parameters such as BUN and creatinine, urine parameters such as albumin excretion rate and protein excretion rate, inflammatory cytokines, oxidative stress, and fibrosis were elevated in CKD\u2010induced animals. Whereas, with the treatment of extract and oil of\n                    <jats:italic>Vetiveria zizanioides<\/jats:italic>\n                    , kidney function was improved in the treatment groups with a significant decrease in BUN, creatinine, albumin and protein excretion rate, MDA, TNF\u2010\u03b1, IL\u20106, and TGF\u2010\u03b21 expression. Treatment with extract and oil showed significant increase in the creatinine and urea clearance, GFR and antioxidant markers such as GSH, catalase, and SOD. Renal structure in the treatment group showed mitigation of fibrosis and tubular atrophy.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500789","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T15:44:48Z","timestamp":1749570288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Hydroalcoholic Extract and Terpene\u2010Rich Oil of\n                    <i>Vetiveria zizanioides<\/i>\n                    L. Roots in Chronic Kidney Disease in Rats"],"prefix":"10.1002","volume":"22","author":[{"given":"Pranali B.","family":"Yeram","sequence":"first","affiliation":[{"name":"Shobhaben Pratapbhai Patel School of Pharmacy &amp; Technology Management SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Deemed to be University  Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amisha","family":"Vora","sequence":"additional","affiliation":[{"name":"Shobhaben Pratapbhai Patel School of Pharmacy &amp; Technology Management SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Deemed to be University  Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh A.","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Shobhaben Pratapbhai Patel School of Pharmacy &amp; Technology Management SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Deemed to be University  Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00365.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2020.08.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-8871-2_1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/806358"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23063284"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00580118"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-021-05917-y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.21887\/ijvsbt.15.2.1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.14232\/abs.2018.1.17-23"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/2515690X221079688"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2021.07.008"},{"key":"e_1_2_9_13_1","first-page":"216","article-title":"Hepatoprotective Activity of Vetiveria zizanioides Linn. 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