{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T13:42:53Z","timestamp":1768743773976,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Two new compounds, 5\u2010methoxymethylmellein (<jats:bold>1<\/jats:bold>) and 6\u2010benzyl\u20102\u2010hydroxy\u20105\u2010methoxy\u20103\u2010methylpyradine (<jats:bold>2<\/jats:bold>), along with nine known compounds (<jats:bold>3\u201311<\/jats:bold>), were obtained from the mangrove endophytic fungus <jats:italic>Diaporthe<\/jats:italic> sp. SCSIO 41011. Their structures were determined based on extensive spectroscopic analysis and by comparison with literature. The absolute configuration of <jats:bold>1<\/jats:bold> was assigned by electronic circular dichroism calculations. The structure of naturally rare compound <jats:bold>2<\/jats:bold> was unambiguously confirmed by single\u2010crystal X\u2010ray diffraction analysis. Notably, compound <jats:bold>4<\/jats:bold> displayed inhibition of lipopolysaccharide\u2010induced nuclear factor kappa B in RAW264.7 macrophages at 20 \u00b5M. It further dose\u2010dependently suppressed receptor activator of nuclear factor\u2010\u03baB ligand\u2010induced osteoclast differentiation in bone marrow macrophage cells with an EC<jats:sub>50<\/jats:sub> value of 19.0 \u00b5M, without observed cytotoxicity. Our findings provided <jats:bold>4<\/jats:bold> as a promising lead compound for the treatment of osteolytic diseases.<\/jats:p>","DOI":"10.1002\/cbdv.202500858","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T21:18:06Z","timestamp":1744665486000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Discovery of Polyketides and Alkaloids From the Mangrove Endophytic Fungus <i>Diaporthe<\/i> sp. and Their Anti\u2010Osteoclastogenic Bioactivities"],"prefix":"10.1002","author":[{"given":"Humu","family":"Lu","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory of Marine Drugs University Engineering Research Center of High\u2010efficient Utilization of Marine Traditional Chinese Medicine Resources Guangxi, Institute of Marine Drugs, Guangxi University of Chinese Medicine  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyao","family":"Feng","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Marine Drugs University Engineering Research Center of High\u2010efficient Utilization of Marine Traditional Chinese Medicine Resources Guangxi, Institute of Marine Drugs, Guangxi University of Chinese Medicine  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaoping","family":"Lin","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Marine Drugs University Engineering Research Center of High\u2010efficient Utilization of Marine Traditional Chinese Medicine Resources Guangxi, Institute of Marine Drugs, Guangxi University of Chinese Medicine  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Marine Drugs University Engineering Research Center of High\u2010efficient Utilization of Marine Traditional Chinese Medicine Resources Guangxi, Institute of Marine Drugs, Guangxi University of Chinese Medicine  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghong","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Marine Drugs University Engineering Research Center of High\u2010efficient Utilization of Marine Traditional Chinese Medicine Resources Guangxi, Institute of Marine Drugs, Guangxi University of Chinese Medicine  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhui","family":"Tan","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences Guangxi Normal University  Guilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2114-1609","authenticated-orcid":false,"given":"Xiaowei","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences Guangxi Normal University  Guilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","article-title":"Osteoporosis: Now and the Future","volume":"377","author":"Rachner T. 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