{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:42:11Z","timestamp":1773013331220,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Osbeckia stellata<\/jats:italic>\n                    Buch.\u2010Ham. ex D. Don (family: Melastomataceae) has been traditionally used to treat asthma, arthritis, diabetes, skin diseases, and toothaches. Therefore, we evaluated the phytochemical profile, antioxidant, in vitro anti\u2010inflammatory, and antibacterial properties using various solvents. The methanol extract exhibited high levels of total phenolic (933.11\u00a0\u00b1\u00a037.29 milligram of gallic acid equivalents per gram [mg\u00a0GAE\/g]), flavonoid (253.05\u00a0\u00b1\u00a06.35 milligram of quercetin equivalent per gram [mg\u00a0QE\/g]), and tannin content (163.13\u00a0\u00b1\u00a014.91\u00a0mg tannin acid equivalents [TAE]\/g). Antioxidant activity was potent with low IC\n                    <jats:sub>50<\/jats:sub>\n                    values in 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl (DPPH) (7.91\u00a0\u00b1\u00a00.57\u00a0\u00b5g\/mL), ABTS (8.13\u00a0\u00b1\u00a01.78\u00a0\u00b5g\/mL) and ferric\u2010reducing antioxidant power (FRAP) (16.48\u00a0\u00b1\u00a00.21\u00a0mg\u00a0AAE\u00a0g\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), and metal\u2010chelating activity (MCA) (23.53\u00a0\u00b1\u00a02.48\u00a0\u00b5g\/mL) assays. In vitro anti\u2010inflammatory activity was significant, with an IC\n                    <jats:sub>50<\/jats:sub>\n                    of 90.82\u00a0\u00b1\u00a02.34\u00a0\u00b5g\/mL. The methanol extract showed antibacterial activity, particularly against\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    . Liquid chromatography\u2013time\u2010of\u2010flight mass spectrometry (LC\u2013TOF\u2010MS) analysis identified bioactive compounds, including flavonoids, triterpenoids, phenolic acids, glycosides, amino acids, and steroid compounds. The results indicate that the solvent's polarity enhances the biological activity of the extracts, supporting the traditional use of this plant as natural medicine.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500861","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T19:04:36Z","timestamp":1752779076000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phytochemical Profiling and In Vitro Evaluation of Biological Activities of\n                    <i>Osbeckia stellata<\/i>\n                    Buch.\u2010Ham. ex D. Don Extracts From the Uttarakhand Himalayas, India"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0910-4195","authenticated-orcid":false,"given":"Jyoti","family":"Darmwal","sequence":"first","affiliation":[{"name":"Department of Chemistry, D.S.B. Campus Kumaun University Nainital Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6053-7883","authenticated-orcid":false,"given":"Pushpa","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, D.S.B. Campus Kumaun University Nainital Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelam","family":"Rawat","sequence":"additional","affiliation":[{"name":"Department of Chemistry, D.S.B. Campus Kumaun University Nainital Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shubham","family":"Kathuria","sequence":"additional","affiliation":[{"name":"Department of Chemistry, D.S.B. Campus Kumaun University Nainital Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megha","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Bhimtal Campus Kumaun University Nainital Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02854894"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/274905"},{"key":"e_1_2_9_4_1","first-page":"6","article-title":"Medicinal Plant Wealth of Oak Dominated Forests in Nainital Catchment Area of Uttarakhand","volume":"2","author":"Shah S.","year":"2014","journal-title":"Academia Journal of Medicinal Plants"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-019-2763-6"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.08.097"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-009-9125-9"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ddc3010011"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.22244\/rheedea.2019.29.4.01"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(01)00319-1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880200600897205"},{"key":"e_1_2_9_12_1","first-page":"77","article-title":"Traditional Phytotherapy Used by Bhutia Community of Uttarkashi District of Uttarakhand for Dermatological Disorders","volume":"11","author":"Agrawal A. 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Don (Melastomataceae) Prevalent of Darjeeling Hills","volume":"5","author":"Das S.","year":"2013","journal-title":"International Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"e_1_2_9_15_1","first-page":"131","article-title":"Folklore use of Osbeckia Species From Munnar Hills, Kerala","volume":"5","author":"Lawarence B.","year":"2017","journal-title":"Journal of Traditional and Folk Practices"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3329\/bjb.v40i1.8005"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880200600897205"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3126\/tuj.v24i1.251"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12257-011-0453-4"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kjs.2024.100229"},{"key":"e_1_2_9_21_1","first-page":"101","article-title":"In Vitro Evaluation of the Antioxidant Potential, Phenolic and Flavonoid Contents of the Stem Bark Ethanol Extract of Anogeissus leiocarpus","volume":"43","author":"Olugbami O. 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