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Consequently, the discovery of novel therapeutic agents for the treatment of diabetes and obesity is of critical importance. In this context, 14 medicinal plants were evaluated in vitro for their inhibitory effects on \u03b1\u2010amylase, \u03b1\u2010glucosidase, and pancreatic lipase that involved in carbohydrate and lipid metabolism. Additionally, the total phenolic and flavonoid contents, along with antioxidant activities of the extracts, were assessed.\n                    <jats:italic>Alhagi maurorum<\/jats:italic>\n                    methanol extract exhibited strong \u03b1\u2010glucosidase (IC\n                    <jats:sub>50<\/jats:sub>\n                    45.16\u00a0\u00b5g\/mL) and moderate pancreatic lipase inhibitory activity (46.47%). Moderate \u03b1\u2010amylase inhibitory activity was observed only in the methanol extracts of\n                    <jats:italic>Crocus ancyrensis<\/jats:italic>\n                    and\n                    <jats:italic>Scabiosa rotata<\/jats:italic>\n                    (38.54% and 28.79%, respectively). Extracts of\n                    <jats:italic>Tilia tomentosa<\/jats:italic>\n                    ,\n                    <jats:italic>Thymus praecox<\/jats:italic>\n                    , and\n                    <jats:italic>Berberis crataegina<\/jats:italic>\n                    , which contained high levels of total phenolics and flavonoids, also demonstrated notable antioxidant activity. Quantitative analysis of chlorogenic acid, rutin, quercetin\u20103\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010glucoside, and hesperidin was carried out using RP\u2010HPLC on the methanol extract of\n                    <jats:italic>A. maurorum<\/jats:italic>\n                    , which showed the most significant \u03b1\u2010glucosidase and lipase inhibition. On the basis of these findings, it can be concluded that activity\u2010guided fractionation of\n                    <jats:italic>A. maurorum<\/jats:italic>\n                    methanol extract may lead to the identification of novel compounds with antidiabetic potential.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500868","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T19:53:41Z","timestamp":1755546821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Selected Medicinal Plants on Enzymatic Targets Related to Diabetes Mellitus and Obesity"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1138-3145","authenticated-orcid":false,"given":"Tu\u011fba","family":"G\u00fcnbatan","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Gazi University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultan","family":"Pekacar","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Gazi University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bur\u00e7in","family":"\u00d6z\u00fcpek","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Gazi University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasya Nazli","family":"G\u00f6k","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Gazi University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didem Deliorman","family":"Orhan","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Gazi University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lhan","family":"G\u00fcrb\u00fcz","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Gazi University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S"},{"key":"e_1_2_8_3_1","unstructured":"WHO Global Report on Diabetes(WHO 2016) https:\/\/www.who.int\/publications\/i\/item\/9789241565257."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02317-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22091563"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.1987"},{"key":"e_1_2_8_7_1","first-page":"2944","article-title":"New Insights Into the Latest Advancement in \u03b1\u2010Amylase Inhibitors of Plant Origin With Anti\u2010Diabetic Effects","volume":"12","author":"Kashtoh H.","year":"2023","journal-title":"Plants (Basel)"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2012.31621"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:13:2:155"},{"key":"e_1_2_8_10_1","volume-title":"Obesity and Overweight","author":"WHO","year":"2025"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/83.3.276"},{"key":"e_1_2_8_12_1","first-page":"1197","article-title":"Current and Investigational Antiobesity Agents and Obesity Therapeutic Treatment Targets","volume":"12","author":"Bays H. 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