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This study unveils the hepatoprotective potential of\n                    <jats:italic>Helicteres hirsuta<\/jats:italic>\n                    Lour. leaf methanol extract for the first time. Antioxidant capacity was assessed using DPPH, ABTS, and total antioxidant assays, while in vivo hepatoprotection was evaluated in a paracetamol\u2010induced liver injury model. The extract exhibits robust antioxidant activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a015.94\u00a0\u00b5g\/mL for DPPH; 18.52\u00a0\u00b5g\/mL for ABTS), roughly twice as effective as curcumin, along with high total antioxidant capacity (133.53\u00a0\u00b1\u00a00.35\u00a0mg GA\/g) and significant reductions in AST, ALT, and MDA levels at 500\u00a0mg\/kg. LC\u2013MS\/MS analysis identifies exceptionally high levels of rutin (310.99\u00a0\u00b1\u00a01.44\u00a0\u00b5g\/g) and catechin (221.79\u00a0\u00b1\u00a02.61\u00a0\u00b5g\/g), approximately 16.6\u2010 and 22.2\u2010fold higher than in\n                    <jats:italic>Nigella sativa<\/jats:italic>\n                    , a well\u2010known medicinal plant. Such achievements highlight\n                    <jats:italic>H. hirsuta<\/jats:italic>\n                    as a promising natural source for liver protection.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500878","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T18:20:06Z","timestamp":1758565206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hepatoprotective and Antioxidant Activities of Methanolic\n                    <i>Helicteres hirsuta<\/i>\n                    Leaf Extract"],"prefix":"10.1002","volume":"22","author":[{"given":"Trung Hieu","family":"Le","sequence":"first","affiliation":[{"name":"Hue University of Sciences\u2013Hue University  Hue City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minh Nhung","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Hue University of Sciences\u2013Hue University  Hue City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi Hong Chuong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Center for Advanced Chemistry Institute of Research and Development, Duy Tan University  Danang Vietnam"},{"name":"Faculty of Natural Sciences Duy Tan University  Danang Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lam Son","family":"Le","sequence":"additional","affiliation":[{"name":"Hue University of Sciences\u2013Hue University  Hue City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan Anh Vu","family":"Ho","sequence":"additional","affiliation":[{"name":"Hue University of Sciences\u2013Hue University  Hue City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanh Minh","family":"Tran","sequence":"additional","affiliation":[{"name":"Hue University of Sciences\u2013Hue University  Hue City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi Van Thi","family":"Tran","sequence":"additional","affiliation":[{"name":"Hue University of Sciences\u2013Hue University  Hue City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi Hong Hanh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Hue University of Sciences\u2013Hue University  Hue City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoang Luong Ngoc","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Hue University of Sciences\u2013Hue University  Hue City Vietnam"},{"name":"Ho Chi Minh City University of Industry and Trade  Ho Chi Minh Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quang","family":"Man Nguyen","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy, Hue University  Hue City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nhat Tam","family":"Le","sequence":"additional","affiliation":[{"name":"Industrial University of Ho Chi Minh City  Ho Chi Minh Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2852-1102","authenticated-orcid":false,"given":"Chinh Chien","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Center for Advanced Chemistry Institute of Research and Development, Duy Tan University  Danang Vietnam"},{"name":"Faculty of Natural Sciences Duy Tan University  Danang Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"114","article-title":"Free Radicals, Oxidative Stress\u2010Related Diseases and Antioxidant Supplementation","volume":"28","author":"Engwa G. 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