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An imbalance in the oxidative\u2013antioxidative system is associated with numerous human diseases. Consequently, exploring natural antioxidants and investigating their impact on human health has become a pivotal research focus. Marine\u2010derived fungi represent a significant resource for discovering natural products due to their structural diversity and broad range of biological activities. This review highlights the potential of marine\u2010derived fungi as sources of antioxidant compounds. A total of 41 studies, describing 168 secondary metabolites with antioxidant properties isolated from 38 marine\u2010derived fungal strains across 19 genera, were reviewed. The sources, unique structures, and bioactivities of these antioxidant compounds were systematically compiled. This review provides a valuable reference for the current research landscape of natural products from marine\u2010derived fungi and reveals that marine natural products have important medicinal values and are worthy of in\u2010depth investigation.<\/jats:p>","DOI":"10.1002\/cbdv.202500901","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T16:29:25Z","timestamp":1750091365000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antioxidant Secondary Metabolites From Marine\u2010Derived Fungi: Chemical Diversity and Bioactivity Profiling"],"prefix":"10.1002","author":[{"given":"Yao\u2010Yao","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Pharmacy Affiliated Hospital of Shandong University of Traditional Chinese Medicine  Jinan China"},{"name":"Laboratory for Molecular Identification and Biological Evaluation of Chinese Herbal Pieces Affiliated Hospital of Shandong University of Traditional Chinese Medicine  Jinan China"},{"name":"MOE Key Laboratory of Marine Drugs and Key Laboratory of Evolution and Marine Biodiversity Institute of Evolution &amp; 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