{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T08:53:43Z","timestamp":1788684823452,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Edible mushrooms exhibit a range of pharmacological activities, including anticancer, antimicrobial, antioxidant, anti\u2010obesity, and hepatoprotective effects, thereby holding significant potential for applications in the development of functional foods. This study aimed to evaluate the bioactivities of methanolic extracts from various edible mushrooms (MEMs) found in the Qinling Mountains, China, with the following species used as materials:\n Suillus granulatus<\/jats:italic>\n (L.) Roussel (\n S. granulatus<\/jats:italic>\n (L.) Roussel),\n Ramaria botrytoides<\/jats:italic>\n (Peck) Corner (\n R. botrytoides<\/jats:italic>\n (Peck) Corner),\n Flammulina velutipes<\/jats:italic>\n (Curtis) Singer (\n F. velutipes<\/jats:italic>\n (Curtis) Singer),\n Agrocybe cylindracea<\/jats:italic>\n (DC.) Maire (\n A. cylindracea<\/jats:italic>\n (DC.) Maire),\n Lentinula edodes<\/jats:italic>\n (Berk.) Sing. (\n L. edodes<\/jats:italic>\n (Berk.) Sing.),\n Hericium erinaceus<\/jats:italic>\n (Bull.) Pers. (\n H. erinaceus<\/jats:italic>\n (Bull.) Pers.), White\n Hypsizygus marmoreus<\/jats:italic>\n (White\n H. marmoreus<\/jats:italic>\n ),\n Auricularia auricular<\/jats:italic>\n (L.ex Hook.) Undew (\n A. auricular<\/jats:italic>\n (L.ex Hook.) Undew),\n Hypsizygus marmoreus<\/jats:italic>\n (white cultivar) (\n H. marmoreus<\/jats:italic>\n (white cultivar)),\n Pleurotus eryngii<\/jats:italic>\n (DC. Fr) Qu. (\n P. eryngii<\/jats:italic>\n (DC. Fr) Qu.),\n Cordyceps militaris<\/jats:italic>\n (L.) Link (\n C. militaris<\/jats:italic>\n (L.) Link),\n Lentinula edodes<\/jats:italic>\n (Berk.) Pegler (\n L. edodes<\/jats:italic>\n (Berk.) Pegler),\n Hypsizygus marmoreus<\/jats:italic>\n (brown cultivar) (\n H. marmoreus<\/jats:italic>\n (brown cultivar)), and\n Morchella esculenta<\/jats:italic>\n (L.) Pers. (\n M. esculenta<\/jats:italic>\n (L.) Pers.). We examined the total polyphenol, total flavonoid, and total polysaccharide content of MEMs. And quantified the 12 monomeric phenolic substances contained in the MEMs by high\u2010performance liquid chromatography. The antioxidant activity\n in vitro<\/jats:italic>\n was studied by determining the DPPH\u2022 scavenging capacity, ABTS\n +<\/jats:sup>\n \u2022 scavenging capacity, and Fe\n 2+<\/jats:sup>\n reduction capacity, whereas the inhibition rates of \u03b1\u2010amylase and pancreatic lipase were used to evaluate the enzyme\u2010inhibiting capacity of each edible mushroom. Significant differences were found in the chemical composition and in vitro activity of the extracts from different sources. Our results showed that\n R. botrytoides<\/jats:italic>\n (Peck) Corner had the highest total polyphenols and flavonoid content, which were 28.57 \u00b1 0.85 and 32.33 \u00b1 0.37\u00a0mg\/g, respectively, among the edible mushrooms. Among the 14 edible mushrooms,\n Pleurotus eryngii<\/jats:italic>\n (DC. Fr) Qu had the highest total polysaccharide content of 503.73 \u00b1 0.24\u00a0mg\/g. The antioxidant activity and pancreatic lipase inhibition of\n R. botrytoides<\/jats:italic>\n (Peck) Corner methanol extract were superior to other edible mushrooms, while\n A. auricular<\/jats:italic>\n (L.ex Hook.) Undew showed the highest inhibition of \u03b1\u2010amylase activity. These results reveal that the active substances in\n R. botrytoides<\/jats:italic>\n (Peck) Corner are abundant and have good antioxidant and enzyme inhibitory capacity, which can provide theoretical support for the subsequent development and utilization of\n R. botrytoides<\/jats:italic>\n (Peck) Corner. These findings help to inform and guide the exploration and development of the species of edible mushrooms, which can serve as a theoretical basis for the advancement of natural functional foods possessing antioxidant, hypoglycemic, and hypolipidemic effects.\n <\/jats:p>","DOI":"10.1002\/cbdv.202500904","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T20:04:07Z","timestamp":1755115447000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Composition Analysis and In Vitro Investigation on Antioxidant, \u03b1\u2010Amylase, and Pancreatic Lipase Inhibitory Activities of Major Mushrooms in Qinling Mountains"],"prefix":"10.1002","volume":"22","author":[{"given":"Shulei","family":"Liu","sequence":"first","affiliation":[{"name":"Chinese\u2010German Joint Laboratory For Natural Product Research Shaanxi Provincial Key Laboratory of Resource Biology Collaborative Innovation Center For Comprehensive Development of Biological Resources in Qin\u2010ba Mountains Southern Shaanxi Province State Key Laboratory of Qin\u2010ba Biological Resources and Ecological Environment College of Biological Science and Engineering Shaanxi University of Technology Hanzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanfan","family":"Jia","sequence":"additional","affiliation":[{"name":"Chinese\u2010German Joint Laboratory For Natural Product Research Shaanxi Provincial Key Laboratory of Resource Biology Collaborative Innovation Center For Comprehensive Development of Biological Resources in Qin\u2010ba Mountains Southern Shaanxi Province State Key Laboratory of Qin\u2010ba Biological Resources and Ecological Environment College of Biological Science and Engineering Shaanxi University of Technology Hanzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuchao","family":"Xie","sequence":"additional","affiliation":[{"name":"Hanzhong Science and Technology Resources Co\u2010ordination Center Hanzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirui","family":"Kang","sequence":"additional","affiliation":[{"name":"Chinese\u2010German Joint Laboratory For Natural Product Research Shaanxi Provincial Key Laboratory of Resource Biology Collaborative Innovation Center For Comprehensive Development of Biological Resources in Qin\u2010ba Mountains Southern Shaanxi Province State Key Laboratory of Qin\u2010ba Biological Resources and Ecological Environment College of Biological Science and Engineering Shaanxi University of Technology Hanzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingke","family":"Feng","sequence":"additional","affiliation":[{"name":"Chinese\u2010German Joint Laboratory For Natural Product Research Shaanxi Provincial Key Laboratory of Resource Biology Collaborative Innovation Center For Comprehensive Development of Biological Resources in Qin\u2010ba Mountains Southern Shaanxi Province State Key Laboratory of Qin\u2010ba Biological Resources and Ecological Environment College of Biological Science and Engineering Shaanxi University of Technology Hanzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Xiong","sequence":"additional","affiliation":[{"name":"Hanzhong Science and Technology Resources Co\u2010ordination Center Hanzhong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beiei","family":"Lin","sequence":"additional","affiliation":[{"name":"Chinese\u2010German Joint Laboratory For Natural Product Research Shaanxi Provincial Key Laboratory of Resource Biology Collaborative Innovation Center For Comprehensive Development of Biological Resources in Qin\u2010ba Mountains Southern Shaanxi Province State Key Laboratory of Qin\u2010ba Biological Resources and Ecological Environment College of Biological Science and Engineering Shaanxi University of 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